Evidence map›Paper›PMID 19347591›Full record

ReviewClinical & experimental metastasis2009

Gene expression profiles and breast cancer metastasis: a genetic perspective.

Kent W Hunter, Jude Alsarraj

Abstract readReview
In one paragraph

Review in Clinical & experimental metastasis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Lung cancer with gastrointestinal metastasis - review of theories of metastasis with three rare case descriptions.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2013
    Article
  4. Article
  5. Article
  6. Genomics screens for metastasis genes.Cancer metastasis reviews · 2012
    Review
  7. A methodological approach to unravel organ-specific breast cancer metastasis.Journal of mammary gland biology and neoplasia · 2012
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kent W HunterLaboratory of Cancer Biology and Genetics, CCR/NCI/NIH, Bethesda, MD 20892-4264, USA. hunterk@mail.nih.gov
Jude Alsarraj

Funding

Genetic Modifiers of Intitiation and Progression of Mammary CancerZIABC011255 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HUNTER, KENT WILLIAM · 2010 to 2025
$33.2M
GENETIC MODIFIERS OF MAMMARY CANCER INITIATION/ PROGRESSZ01CP010146 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI HUNTER, KENT WILLIAM · 2000 to 2008
$3.3M
Genetic Modifiers of Intitiation and Progression of Mammary CancerZIACP010146 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI HUNTER, KENT WILLIAM · 2009 to 2009
$1.7M
Intramural NIH HHS Z01 CP010146
6 · The paper itself

Abstract

The majority of cancer mortality is attributed to metastasis, which is the spread of tumor cells to a secondary site. Several studies have demonstrated that the genetic background on which a tumor arises has a major effect on both metastatic efficiency and on predictive gene expression profiles. These observations suggest that there is variability in metastasis frequency between individuals and that some individuals could be more prone to secondary tumor formation and development than others. Thus, genetic background might have important clinical implications in metastasis detection, management and prevention.

Indexed as

Gene Expression ProfilingBreast NeoplasmsFemaleHumansNeoplasm MetastasisPolymorphism, Genetic

Identifiers

PMID19347591
PMCPMC6563922

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.