ArticleOncogene2009
Stanniocalcin-1 acts in a negative feedback loop in the prosurvival ERK1/2 signaling pathway during oxidative stress.
Article in Oncogene, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 58 citations in OpenAlex.
- Study on the anti-lung cancer effects of Gracillin from Reineckia carnea by targeting STC1.BMC cancer · 2026Article
- Necroptosis-based glioblastoma prognostic subtypes: implications for TME remodeling and therapy response.Annals of medicine · 2024Article
- Stanniocalcin-1 Promotes PARP1-Dependent Cell Death via JNK Activation in Colitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Identification and characterization of a membrane receptor that binds to human STC1.Life science alliance · 2022Article
- Runs of homozygosity in Swiss goats reveal genetic changes associated with domestication and modern selection.Genetics, selection, evolution : GSE · 2022Article
- Transgene expression of Stanniocalcin-1 provides sustained intraocular pressure reduction by increasing outflow facility.PloS one · 2022Article
- Article
- Stanniocalcin-1 Reduced Intraocular Pressure in Two Models of Ocular Hypertension.Current eye research · 2021Article
- Molecular and Clinical Significance of Stanniocalcin-1 Expression in Breast Cancer Through Promotion of Homologous Recombination-Mediated DNA Damage Repair.Frontiers in cell and developmental biology · 2021Article
- Characterization of stanniocalcin-1 expression in macrophage differentiation.Translational oncology · 2021Article
- Expression, function and clinical application of stanniocalcin-1 in cancer.Journal of cellular and molecular medicine · 2020Review
- The stress-activated protein kinase pathway and the expression of stanniocalcin-1 are regulated by miR-146b-5p in papillary thyroid carcinogenesis.Cancer biology & therapy · 2020Article
- Stanniocalcin-1 is a Modifier of Oxygen-Induced Retinopathy Severity.Current eye research · 2020Article
- Stanniocalcin 1 in tumor microenvironment promotes metastasis of ovarian cancer.OncoTargets and therapy · 2019Article
- Effects of STC1 overexpression on tumorigenicity and metabolism of hepatocellular carcinoma.Oncotarget · 2018Article
- Long-term photoreceptor rescue in two rodent models of retinitis pigmentosa by adeno-associated virus delivery of Stanniocalcin-1.Experimental eye research · 2017Article
- Stanniocalcin-1 attenuates ischemic cardiac injury and response of differentiating monocytes/macrophages to inflammatory stimuli.Translational research : the journal of laboratory and clinical medicine · 2016Article
- Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies.Oxidative medicine and cellular longevity · 2016Review
- Hypoxia-induced overexpression of stanniocalcin-1 is associated with the metastasis of early stage clear cell renal cell carcinoma.Journal of translational medicine · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian Stanniocalcin-1 (STC1) is a glycoprotein that has been implicated in various biological processes including angiogenesis. Aberrant STC1 expression has been reported in breast, ovarian and prostate cancers, but the significance of this is not well understood. Here, we report that oxidative stress caused a 40-fold increase in STC1 levels in mouse embryo fibroblasts (MEFs). STC1-/- MEFs were resistant to growth inhibition and cell death induced by H(2)O(2) or by 20% O(2) (which is hyperoxic for most mammalian cells); this is the first phenotype reported for STC1-null cells. STC1-/- cells had higher levels of activated MEK and ERK1/2 than their wild-type (WT) counterparts, and these levels were all reduced by stable expression of exogenous STC1 in STC1-/- cells. Furthermore, pharmacological inhibition by PD98059 or UO126 of MEK and therefore of ERK1/2 activation restored sensitivity of STC1-/- cells to oxidative stress. We also found that H(2)O(2)-induced STC1 expression in WT cells was abolished by inhibition of ERK1/2 activation. Thus, the ERK1/2 signaling pathway upregulates STC1 expression, which in turn downregulates the level of activated MEK and consequently ERK1/2 in a novel negative feedback loop. Therefore, STC1 expression downregulates prosurvival ERK1/2 signaling and reduces survival under conditions of oxidative stress.
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