ReviewNature reviews. Gastroenterology & hepatology2009
Mechanisms of HCV survival in the host.
Review in Nature reviews. Gastroenterology & hepatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- B cells expressing mutated IGHV1-69-encoded antigen receptors related to virus neutralization show lymphoma-like transcriptomes in patients with chronic HCV infection.Hepatology communications · 2024Article
- Toll-like Receptor Response to Hepatitis C Virus Infection: A Recent Overview.International journal of molecular sciences · 2022Review
- Structural and Epitope Analysis (T- and B-Cell Epitopes) of Hepatitis C Virus (HCV) Glycoproteins: AnJournal of clinical and experimental hepatology · 2018Article
- Oxidative Stress and Immune Responses During Hepatitis C Virus Infection in Tupaia belangeri.Scientific reports · 2017Article
- What is the Risk of Graft Reinfection in Case of Liver Transplantation for Patients With Acute HEV or HAV Infection?Journal of clinical and experimental hepatology · 2017Article
- HCV-Induced Oxidative Stress: Battlefield-Winning Strategy.Oxidative medicine and cellular longevity · 2016Review
- Vinexin β Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation.Journal of virology · 2015Article
- Antigenic cooperation among intrahost HCV variants organized into a complex network of cross-immunoreactivity.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A novel approach to identify candidate prognostic factors for hepatitis C treatment response integrating clinical and viral genetic data.Evolutionary bioinformatics online · 2015Article
- Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice.Cell research · 2014Article
- Article
- Mixing the right hepatitis C inhibitor cocktail.Trends in molecular medicine · 2011Review
- Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment.Journal of translational medicine · 2010Review
- Host genetic basis for hepatitis C virus clearance: a role for blood collection centers.Current opinion in hematology · 2010Review
- Regulation of host innate immunity by hepatitis C virus: crosstalk between hepatocyte and NK/DC.Reviews in infection · 2010Article
- Viperin is highly induced in neutrophils and macrophages during acute and chronic lymphocytic choriomeningitis virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Common threads in persistent viral infections.Journal of virology · 2010Review
- Activation of natural killer cells during acute infection with hepatitis C virus.Gastroenterology · 2010Article
- Genomic scale analysis of racial impact on response to IFN-alpha.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- The evolution of the major hepatitis C genotypes correlates with clinical response to interferon therapy.PloS one · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
HCV infection is an important cause of liver disease worldwide-nearly 80% of infected patients develop chronic liver disease, which leads to the development of liver cirrhosis and hepatocellular carcinoma. The ability of HCV to persist within a host is believed to be related to the numerous mechanisms by which it evades the immune response of the host. These mechanisms can be divided into defensive and offensive strategies. Examples of defensive mechanisms include replication within enclosed structures, which provides protection from the host's antiviral defenses, genetic diversity created by inaccurate replication, which yields mutants resistant to the cell's antiviral strategies, and association of the virion with protective lipoproteins. Offensive mechanisms include virally encoded proteins and other factors that disrupt the ability of the host cells to detect the virus and downregulate its ability to respond to interferon, impair innate immune defense mechanisms and alter T-cell responses, and prevent the development of an effective B-cell-mediated humoral response. Greater understanding of these viral survival strategies will ultimately translate into more effective antiviral therapies and better prognosis for patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.