ArticleMedicine and science in sports and exercise2009
Myostatin and follistatin polymorphisms interact with muscle phenotypes and ethnicity.
Article in Medicine and science in sports and exercise, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Pooled it
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- Genetics and sports performance: the present and future in the identification of talent for sports based on DNA testing.European journal of applied physiology · 2022Review
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- Polygenic Models Partially Predict Muscle Size and Strength but Not Low Muscle Mass in Older Women.Genes · 2022Article
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- Genetic characteristics of competitive swimmers: a review.Biology of sport · 2022Review
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- An intron variant of the GLI family zinc finger 3 (GLI3) gene differentiates resistance training-induced muscle fiber hypertrophy in younger men.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Myostatin A55T Genotype is Associated with Strength Recovery Following Exercise-Induced Muscle Damage.International journal of environmental research and public health · 2020Article
- Chronic activity-based therapy does not improve body composition, insulin-like growth factor-I, adiponectin, or myostatin in persons with spinal cord injury.The journal of spinal cord medicine · 2015Article
- The potential role of myostatin and neurotransmission genes in elite sport performances.Journal of biosciences · 2015Article
- Scientometric analyses of studies on the role of innate variation in athletic performance.SpringerPlus · 2014Article
- Association of the K153R polymorphism in the myostatin gene and extreme longevity.Age (Dordrecht, Netherlands) · 2013Article
- From gene engineering to gene modulation and manipulation: can we prevent or detect gene doping in sports?Sports medicine (Auckland, N.Z.) · 2013Review
- Genes and the ageing muscle: a review on genetic association studies.Age (Dordrecht, Netherlands) · 2013Review
- Highlights from the functional single nucleotide polymorphisms associated with human muscle size and strength or FAMuSS study.BioMed research international · 2013Article
- Variants of the ankyrin repeat domain 6 gene (ANKRD6) and muscle and physical activity phenotypes among European-derived American adults.Journal of strength and conditioning research · 2012Article
Corrections and comments
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Authors and funding
14 authors at 10 institutions in 2 countries.
Funding
Abstract
purposeWe examined associations among myostatin (MSTN) 2379 A > G and 163 G > A and follistatin (FST) -5003 A > T and -833 G > T single nucleotide polymorphisms (SNP) on the muscle size and the strength response to resistance training (RT).
methodsSubjects (n = 645, age = 24.1 +/- 0.2 yr, body mass index [BMI] = 24.2 +/- 0.2 kg x m(-2)) self-disclosed themselves as Caucasian (78.9%), African American (3.6%), Asian (8.4%), Hispanic (5.0%), or Other (4.2%). They were genotyped for MSTN 2379 A > G (n = 645), MSTN 163 G > A (n = 639), FST -5003 A > T (n = 580), and FST -833 G > T (n = 603). We assessed dynamic (one repetition maximum [1RM]) and isometric (maximum voluntary contraction [MVC]) muscle strength and size (cross-sectional area [CSA]) of the elbow flexors before and after 12 wk of unilateral upper-arm RT. Repeated-measures ANCOVA tested associations among genetic variants and muscle phenotypes with age and BMI as covariates.
resultsBaseline MVC was greater among African Americans who were carriers of the MSTN G(2379) allele (AG/GG, n = 15) than the A2379A homozygotes (n = 8; 64.2 +/- 6.8 vs 49.8 +/- 8.7 kg). African Americans who were carriers of the FST T(-5003) allele (n = 12) had greater baseline 1RM (11.9 +/- 0.7 vs 8.8 +/- 0.5 kg) and CSA (24.4 +/- 1.3 vs 19.1 +/- 1.2 cm(2)) than African Americans with the A-5003A genotype (n = 14; P < 0.05). No MSTN or FST genotype and muscle phenotype associations were found among the other ethnic groups (P >or= 0.05).
conclusionMSTN 2379 A > G and FST -5003 A > T were associated with baseline muscle strength and size among African Americans only. These ethnic-specific associations are hypothesis generating and should be confirmed in a larger sample of African Americans.
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