ArticleProceedings of the National Academy of Sciences of the United States of America2009
Switching direction in electric-signal-induced cell migration by cyclic guanosine monophosphate and phosphatidylinositol signaling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02623660 (Accelerated Reduction of Post-operative Edema and Early Return to Function Following Total Knee Arthroplasty), which is not on this map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Accelerated Reduction of Post-operative Edema and Early Return to Function Following Total Knee Arthroplasty (TKA)
Who cites it
54 citing papers in PubMed, 119 citations in OpenAlex.
- Excitable Ras dynamics-based screens reveal RasGEFX is required for macropinocytosis and random cell migration.Nature communications · 2025Article
- Electrotaxis of Dictyostelium discoideum, Migration in an Electric Field.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Pseudopod Tracking and Statistics During Cell Movement in Buffer and Chemotaxis.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Spontaneous signal generation by an excitable system for cell migration.Frontiers in cell and developmental biology · 2024Review
- Electrotaxis evokes directional separation of co-cultured keratinocytes and fibroblasts.Scientific reports · 2023Article
- Stimulation strategies for electrical and magnetic modulation of cells and tissues.Cell regeneration (London, England) · 2023Review
- Electric field-guided collective motility initiation of large epidermal cell groups.Molecular biology of the cell · 2023Article
- Physiological Electric Field: A Potential Construction Regulator of Human Brain Organoids.International journal of molecular sciences · 2022Review
- Article
- Actin Dynamics as a Multiscale Integrator of Cellular Guidance Cues.Frontiers in cell and developmental biology · 2022Article
- Pulsed Electrical Stimulation Enhances Consistency of Directional Migration of Adipose-Derived Stem Cells.Cells · 2021Article
- Electric signals counterbalanced posterior vs anterior PTEN signaling in directed migration of Dictyostelium.Cell & bioscience · 2021Article
- Electrotaxis-on-Chip to Quantify Neutrophil Migration Towards Electrochemical Gradients.Frontiers in immunology · 2021Article
- Migration of Human Renal Tubular Epithelial Cells in Response to Physiological Electric Signals.Frontiers in cell and developmental biology · 2021Article
- Optimization of Electrical Stimulation for Safe and Effective Guidance of Human Cells.Bioelectricity · 2020Article
- Novel Electrode Designs for Neurostimulation in Regenerative Medicine: Activation of Stem Cells.Bioelectricity · 2020Review
- Article
- Cellular velocity, electrical persistence and sensing in developed and vegetative cells during electrotaxis.PloS one · 2020Article
- Controlling properties of human neural progenitor cells using 2D and 3D conductive polymer scaffolds.Scientific reports · 2019Article
- Cell migration directionality and speed are independently regulated by RasG and Gβ inBiology open · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Switching between attractive and repulsive migration in cell movement in response to extracellular guidance cues has been found in various cell types and is an important cellular function for translocation during cellular and developmental processes. Here we show that the preferential direction of migration during electrotaxis in Dictyostelium cells can be reversed by genetically modulating both guanylyl cyclases (GCases) and the cyclic guanosine monophosphate (cGMP)-binding protein C (GbpC) in combination with the inhibition of phosphatidylinositol-3-OH kinases (PI3Ks). The PI3K-dependent pathway is involved in cathode-directed migration under a direct-current electric field. The catalytic domains of soluble GCase (sGC) and GbpC also mediate cathode-directed signaling via cGMP, whereas the N-terminal domain of sGC mediates anode-directed signaling in conjunction with both the inhibition of PI3Ks and cGMP production. These observations provide an identification of the genes required for directional switching in electrotaxis and suggest that a parallel processing of electric signals, in which multiple-signaling pathways act to bias cell movement toward the cathode or anode, is used to determine the direction of migration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.