ArticleEukaryotic cell2009
Endoplasmic reticulum-associated secretory proteins Sec20p, Sec39p, and Dsl1p are involved in peroxisome biogenesis.
Article in Eukaryotic cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- SYNTAXIN OF PLANTS81 regulates root meristem activity and stem cell niche maintenance via ROS signaling.Plant physiology · 2023Article
- Peroxisomal Membrane Contact Sites in Yeasts.Frontiers in cell and developmental biology · 2021Review
- Peroxisomes Implicated in the Biosynthesis of Siderophores and Biotin, Cell Wall Integrity, Autophagy, and Response to Hydrogen Peroxide in the Citrus Pathogenic FungusFrontiers in microbiology · 2021Article
- Peroxisome prognostications: Exploring the birth, life, and death of an organelle.The Journal of cell biology · 2020Review
- Peroxisome biogenesis, membrane contact sites, and quality control.EMBO reports · 2019Review
- Nuclear envelope expansion in budding yeast is independent of cell growth and does not determine nuclear volume.Molecular biology of the cell · 2019Article
- ESCRT-III is required for scissioning new peroxisomes from the endoplasmic reticulum.The Journal of cell biology · 2018Article
- Assembly-hub function of ER-localized SNARE proteins in biogenesis of tombusvirus replication compartment.PLoS pathogens · 2018Article
- Extreme genome diversity in the hyper-prevalent parasitic eukaryote Blastocystis.PLoS biology · 2017Article
- Peroxins Pex30 and Pex29 Dynamically Associate with Reticulons to Regulate Peroxisome Biogenesis from the Endoplasmic Reticulum.The Journal of biological chemistry · 2016Article
- Mutant power: using mutant allele collections for yeast functional genomics.Briefings in functional genomics · 2016Review
- Comprehensive proteomics analysis of glycosomes from Leishmania donovani.Omics : a journal of integrative biology · 2015Article
- Article
- Moonlighting functions of the NRZ (mammalian Dsl1) complex.Frontiers in cell and developmental biology · 2014Review
- Peroxisomes take shape.Nature reviews. Molecular cell biology · 2013Review
- Emerging role of the endoplasmic reticulum in peroxisome biogenesis.Frontiers in physiology · 2013Review
- A combined approach of quantitative interaction proteomics and live-cell imaging reveals a regulatory role for endoplasmic reticulum (ER) reticulon homology proteins in peroxisome biogenesis.Molecular & cellular proteomics : MCP · 2013Article
- Article
- Lipid droplets and peroxisomes: key players in cellular lipid homeostasis or a matter of fat--store 'em up or burn 'em down.Genetics · 2013Review
- Plant peroxisomes: biogenesis and function.The Plant cell · 2012Review
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3 authors.
Funding
Abstract
Two pathways have been identified for peroxisome formation: (i) growth and division and (ii) de novo synthesis. Recent experiments determined that peroxisomes originate at the endoplasmic reticulum (ER). Although many proteins have been implicated in the peroxisome biogenic program, no proteins in the eukaryotic secretory pathway have been identified as having roles in peroxisome formation. Using the yeast Saccharomyces cerevisiae regulatable Tet promoter Hughes clone collection, we found that repression of the ER-associated secretory proteins Sec20p and Sec39p resulted in mislocalization of the peroxisomal matrix protein chimera Pot1p-green fluorescent protein (GFP) to the cytosol. Likewise, the peroxisomal membrane protein chimera Pex3p-GFP localized to tubular-vesicular structures in cells suppressed for Sec20p, Sec39p, and Dsl1p, which form a complex at the ER. Loss of Sec39p attenuated formation of Pex3p-derived peroxisomal structures following galactose induction of Pex3p-GFP expression from the GAL1 promoter. Expression of Sec20p, Sec39p, and Dsl1p was moderately increased in yeast grown under conditions that proliferate peroxisomes, and Sec20p, Sec39p, and Dsl1p were found to cofractionate with peroxisomes and colocalize with Pex3p-monomeric red fluorescent protein under these conditions. Our results show that SEC20, SEC39, and DSL1 are essential secretory genes involved in the early stages of peroxisome assembly, and this work is the first to identify and characterize an ER-associated secretory machinery involved in peroxisome biogenesis.
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