ArticleApplied and environmental microbiology2009
Genome-scale model of Streptococcus thermophilus LMG18311 for metabolic comparison of lactic acid bacteria.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 129 citations in OpenAlex.
- Article
- Highlighting Lactic Acid Bacteria in Beverages: Diversity, Fermentation, Challenges, and Future Perspectives.Foods (Basel, Switzerland) · 2025Review
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- Impact of Different Carbon Sources on Volatile Organic Compounds (VOCs) Produced during Fermentation byMolecules (Basel, Switzerland) · 2024Article
- Volatile Organic Compounds (VOCs) Produced byMolecules (Basel, Switzerland) · 2024Article
- Microbial interactions shape cheese flavour formation.Nature communications · 2023Article
- DLTKcat: deep learning-based prediction of temperature-dependent enzyme turnover rates.Briefings in bioinformatics · 2023Article
- From genotype to phenotype: computational approaches for inferring microbial traits relevant to the food industry.FEMS microbiology reviews · 2023Review
- A Two-Compartment Fermentation System to Quantify Strain-Specific Interactions in Microbial Co-Cultures.Bioengineering (Basel, Switzerland) · 2023Article
- Differential Amino Acid Uptake and Depletion in Mono-Cultures and Co-Cultures ofMicroorganisms · 2022Article
- Systematic assessment of template-based genome-scale metabolic models created with the BiGG Integration Tool.Journal of integrative bioinformatics · 2022Article
- Genome-Scale Metabolic Modeling Combined with Transcriptome Profiling Provides Mechanistic Understanding of Streptococcus thermophilus CH8 Metabolism.Applied and environmental microbiology · 2022Article
- In Streptococcus thermophilus, Ammonia from Urea Hydrolysis Paradoxically Boosts Acidification and Reveals a New Regulatory Mechanism of Glycolysis.Microbiology spectrum · 2022Article
- Article
- Omics Approaches to Assess Flavor Development in Cheese.Foods (Basel, Switzerland) · 2022Review
- Identifying the essential nutritional requirements of the probiotic bacteria Bifidobacterium animalis and Bifidobacterium longum through genome-scale modeling.NPJ systems biology and applications · 2021Article
- Role of the Sortase A in the Release of Cell-Wall Proteinase PrtS in the Growth Medium ofMicroorganisms · 2021Article
- Traditional Bulgarian Dairy Products: Ethnic Foods with Health Benefits.Microorganisms · 2021Review
- Dynamic co-culture metabolic models reveal the fermentation dynamics, metabolic capacities and interplays of cheese starter cultures.Biotechnology and bioengineering · 2021Article
- Diversity and specificity of the bacterial community in Chinese horse milk cheese.MicrobiologyOpen · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this report, we describe the amino acid metabolism and amino acid dependency of the dairy bacterium Streptococcus thermophilus LMG18311 and compare them with those of two other characterized lactic acid bacteria, Lactococcus lactis and Lactobacillus plantarum. Through the construction of a genome-scale metabolic model of S. thermophilus, the metabolic differences between the three bacteria were visualized by direct projection on a metabolic map. The comparative analysis revealed the minimal amino acid auxotrophy (only histidine and methionine or cysteine) of S. thermophilus LMG18311 and the broad variety of volatiles produced from amino acids compared to the other two bacteria. It also revealed the limited number of pyruvate branches, forcing this strain to use the homofermentative metabolism for growth optimization. In addition, some industrially relevant features could be identified in S. thermophilus, such as the unique pathway for acetaldehyde (yogurt flavor) production and the absence of a complete pentose phosphate pathway.
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