ArticleApplied and environmental microbiology2009
Phenotypic diversity of infectious red sea bream iridovirus isolates from cultured fish in Japan.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 49 citations in OpenAlex.
- Immunological Responses and Protection in the Largemouth Bass (Animals : an open access journal from MDPI · 2025Article
- Emergence of Decapod iridescent virus 1 in cultured shrimp from Taiwan in 2020.Veterinary medicine and science · 2023Article
- The Inactivated ISKNV-I Vaccine Confers Highly Effective Cross-Protection against Epidemic RSIV-I and RSIV-II from Cultured Spotted Sea Bass Lateolabrax maculatus.Microbiology spectrum · 2023Article
- Genetic differentiation of Megalocytivirus by real time PCR and sequencing.Molecular biology reports · 2023Article
- Isolation, Characterization, and Transcriptome Analysis of an ISKNV-Like Virus from Largemouth Bass.Viruses · 2023Article
- Genotypic Characterization ofTransboundary and emerging diseases · 2023Article
- Singapore Grouper Iridovirus Induces Glucose Metabolism in Infected Cells by Activation of Mammalian Target of Rapamycin Signaling.Frontiers in microbiology · 2022Article
- Environmental Viral Metagenomics Analyses in Aquaculture: Applications in Epidemiology and Disease Control.Frontiers in microbiology · 2016Review
- P247 and p523: two in vivo-expressed megalocytivirus proteins that induce protective immunity and are essential to viral infection.PloS one · 2015Article
- Megalocytiviruses.Viruses · 2012Review
- Shift of phylogenic position in megalocytiviruses based on three different genes.Journal of microbiology (Seoul, Korea) · 2011Article
- Genetic analysis of fish iridoviruses isolated in Taiwan during 2001-2009.Archives of virology · 2011Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Megalocytivirus is causing economically serious mass mortality by infecting fish in and around the Pacific region of Asia. The recent emergence of many new iridoviruses has drawn attention to the marked taxonomic variation within this virus family. Most studies of these viruses have not included extensive study of these emergent species. We explored the emergence of red sea bream iridovirus (RSIV) on a fish farm in Japan, and we specifically endeavored to quantify genetic and phenotypic differences between RSIV isolates using in vitro and in vivo methods. The three isolates had identical major capsid protein sequences, and they were closely related to Korean RSIV isolates. In vitro studies revealed that the isolates differed in replication rate, which was determined by real-time quantitative PCR of viral genomes in infected cells and cell culture supernatant, and in cell viability, estimated by the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay for infected cells. In vivo studies showed that the isolates exhibit different virulence characteristics: infected red sea bream showed either acute death or subacute death according to infection with different isolates. Significant differences were seen in the antigenicity of isolates by a formalin-inactivated vaccine test. These results revealed that variant characteristics exist in the same phylogenetic location in emergent iridoviruses. We suggest that this strain variation would expand the host range in iridoviral epidemics.
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