ArticleClinical and experimental immunology1991
T cell response to purified filtrate antigen 85 from Mycobacterium bovis Bacilli Calmette-Guérin (BCG) in leprosy patients.
Article in Clinical and experimental immunology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Adhesion molecules facilitate host-pathogen interaction & mediateThe Indian journal of medical research · 2019Review
- T cell reactivity against mycolyl transferase antigen 85 of M. tuberculosis in HIV-TB coinfected subjects and in AIDS patients suffering from tuberculosis and nontuberculous mycobacterial infections.Clinical & developmental immunology · 2011Article
- Immunogenicity and protective efficacy of tuberculosis DNA vaccines combining mycolyl-transferase Ag85A and phosphate transport receptor PstS-3.Immunology · 2006Article
- Differential production of systemic and intralesional gamma interferon and interleukin-10 in nodular and ulcerative forms of Buruli disease.Infection and immunity · 2004Article
- Improved tuberculosis DNA vaccines by formulation in cationic lipids.Infection and immunity · 2002Article
- Human T cell responses to peptides of the Mycobacterium leprae 45-kD serine-rich antigen.Clinical and experimental immunology · 2002Article
- Protective efficacy of a DNA vaccine encoding antigen 85A from Mycobacterium bovis BCG against Buruli ulcer.Infection and immunity · 2001Article
- Presence of human T-cell responses to the Mycobacterium leprae 45-kilodalton antigen reflects infection with or exposure to M. leprae.Clinical and diagnostic laboratory immunology · 2001Article
- Pathophysiology of antigen 85 in patients with active tuberculosis: antigen 85 circulates as complexes with fibronectin and immunoglobulin G.Infection and immunity · 1999Article
- Lack of cytotoxic activity against Mycobacterium leprae 65-kD heat shock protein (hsp) in multibacillary leprosy patients.Clinical and experimental immunology · 1995Article
- Fibronectin-binding antigen 85 and the 10-kilodalton GroES-related heat shock protein are the predominant TH-1 response inducers in leprosy contacts.Infection and immunity · 1995Article
- T-cell-epitope mapping of the major secreted mycobacterial antigen Ag85A in tuberculosis and leprosy.Infection and immunity · 1994Article
- T cell reactivity against antigen 85 but not against the 18- and 65-kD heat shock proteins in the early stages of acquired immunity against Mycobacterium leprae.Clinical and experimental immunology · 1994Article
- Mapping of TH1 helper T-cell epitopes on major secreted mycobacterial antigen 85A in mice infected with live Mycobacterium bovis BCG.Infection and immunity · 1994Article
- The Mycobacterium bovis 32-kilodalton protein antigen induces human cytotoxic T-cell responses.Infection and immunity · 1994Article
- Characterization of a Mycobacterium leprae antigen related to the secreted Mycobacterium tuberculosis protein MPT32.Infection and immunity · 1994Article
- Influence of genes from the major histocompatibility complex on the antibody repertoire against culture filtrate antigens in mice infected with live Mycobacterium bovis BCG.Infection and immunity · 1993Article
- The antigen 85 complex: a major secretion product of Mycobacterium tuberculosis.Microbiological reviews · 1992Review
- Mycobacterium leprae produces extracellular homologs of the antigen 85 complex.Infection and immunity · 1992Article
- Rapid detection of tuberculous and non-tuberculous mycobacteria by polymerase chain reaction amplification of a 162 bp DNA fragment from antigen 85.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1992Article
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8 authors.
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Abstract
T cell proliferation and IFN-gamma production of peripheral blood mononuclear cells from 25 healthy controls and 39 leprosy patients were tested against BCG-bacilli and culture filtrate. Mycobacterium leprae and purified antigen 85 (the major secreted 30-32 kD protein antigen) from M. bovis strain BCG. In lepromin negative healthy controls, blastogenesis was low to M. leprae and completely negative to antigen 85. IFN-gamma levels were very low, close to detection limits. In all lepromin positive controls, significant proliferation and IFN-gamma secretion was found in response to M. leprae and antigen 85. In the group of lepromatous leprosy (LL) patients, 25/29 of patients (with either positive (13) or negative (12) lymphoproliferative response to BCG) were unreactive to M. leprae or to antigen 85. Four LL patients with positive T cell response to BCG responded with detectable lymphoproliferative response and IFN-gamma secretion to antigen 85. All tuberculoid (TT) leprosy patients responded to BCG, M. leprae and antigen 85. Hence, T cells from leprosy patients and controls demonstrate a marked parallelism of responsiveness towards whole M. leprae and purified antigen 85 from M. bovis BCG, suggesting strong cross-reactivity between the two species and underlining the biological importance of such secreted antigens.
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