Evidence map›Paper›PMID 19345787›Full record

SynthesisArchives of physical medicine and rehabilitation2009

A systematic review of the management of autonomic dysreflexia after spinal cord injury.

Andrei Krassioukov, Darren E Warburton, Robert Teasell, Janice J Eng, Spinal Cord Injury Rehabilitation Evidence Research Team

3 registry-linked trialsAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Archives of physical medicine and rehabilitation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 150 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 5 pooled it
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03924388 naunknown statusnot on this mapstarted 2020, after this paper: background citation

The Effects of Spinal Cord Stimulation on Autonomic Function in People With Spinal Cord Injury

TypeinterventionalSponsorUniversity of CalgaryRan2020 to 2022Enrolled46ConditionsSpinal Cord Injuries, Autonomic Dysreflexia, Orthostatic Hypotension, DysautonomicArmsEpidural spinal cord stimulation, Trnascutaneous electrical spinal cord stimulation.
NCT05111093 narecruitingnot on this mapstarted 2021, after this paper: background citation

Epidural Electrical Stimulation to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury

TypeinterventionalSponsorEcole Polytechnique Fédérale de LausanneRan2021 to 2030Enrolled20ConditionsSpinal Cord InjuriesArmsARC-IM Investigational System implantation
NCT06587841 narecruitingnot on this mapstarted 2024, after this paper: background citation

Noninvasive Spinal Cord Neuromodulation to Improve Lower Urinary Tract Function After Spinal Cord Injury in Ukrainian War Veterans

TypeinterventionalSponsorUniversity of British ColumbiaRan2024 to 2027Enrolled60ConditionsSpinal Cord Injuries, Bowel Dysfunction, Sexual Dysfunction, Autonomic DysfunctionArmsSpinal COrd NEuromodulation™ (SCONE™) for transcutaneous spinal cord stimulation (TSCS)
3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 5 syntheses or guidelines pooled it, 396 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
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  9. Orthostatic responses to anticholinesterase inhibition in spinal cord injury.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2015
    Trial
  10. Trial
  11. Review
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  14. Review
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90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Andrei KrassioukovInternational Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada.
Darren E Warburton
Robert Teasell
Janice J Eng
Spinal Cord Injury Rehabilitation Evidence Research Team
University of British Columbia · CAWestern University · CA

Funding

CIHR 63617
6 · The paper itself

Abstract

objectiveTo review systematically the clinical evidence on strategies to prevent and manage autonomic dysreflexia (AD). DATA SOURCES: A key word search of several databases (Medline, CINAHL, EMBASE, and PsycINFO), in addition to manual searches of retrieved articles, was undertaken to identify all English-language literature evaluating the efficacy of interventions for AD. STUDY SELECTION: Studies selected for review included randomized controlled trials (RCTs), prospective cohort studies, and cross-sectional studies. Treatments reviewed included pharmacologic and nonpharmacologic interventions for the management of AD in subjects with spinal cord injury. Studies that failed to assess AD outcomes (eg, blood pressure) or symptoms (eg, headaches, sweating) were excluded. DATA EXTRACTION: Studies were critically reviewed and assessed for their methodologic quality by 2 independent reviewers. DATA SYNTHESIS: Thirty-one studies were assessed, including 6 RCTs. Preventative strategies to reduce the episodes of AD caused by common triggers (eg, urogenital system, surgery) primarily were supported by level 4 (pre-post studies) and level 5 (observational studies) evidence. The initial acute nonpharmacologic management of an episode of AD (ie, positioning the patient upright, loosening tight clothing, eliminating any precipitating stimulus) is supported by clinical consensus and physiologic data (level 5 evidence). The use of antihypertensive drugs in the presence of sustained elevated blood pressure is supported by level 1 (prazosin) and level 2 evidence (nifedipine and prostaglandin E(2)).

conclusionsA variety of options are available to prevent AD (eg, surgical, pharmacologic) and manage the acute episode (elimination of triggers, pharmacologic); however, these options are predominantly supported by evidence from noncontrolled trials, and more rigorous trials are required.

Indexed as

Autonomic DysreflexiaFemaleHumansPregnancyPregnancy ComplicationsSpinal Cord Injuries

Identifiers

PMID19345787
PMCPMC3108991
OpenAlexW1977435646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.