ArticleBiochimica et biophysica acta2009
Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae.
Article in Biochimica et biophysica acta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Vps1 and select autophagic machinery are required for coenzyme Q uptake and trafficking to mitochondria.The Journal of biological chemistry · 2026Article
- New Insights on the Uptake and Trafficking of Coenzyme Q.Antioxidants (Basel, Switzerland) · 2023Review
- Coenzyme Q biochemistry and biosynthesis.Trends in biochemical sciences · 2023Review
- Gregarine single-cell transcriptomics reveals differential mitochondrial remodeling and adaptation in apicomplexans.BMC biology · 2021Article
- Article
- Genes and lipids that impact uptake and assimilation of exogenous coenzyme Q in Saccharomyces cerevisiae.Free radical biology & medicine · 2020Article
- Prenylquinones in Human Parasitic Protozoa: Biosynthesis, Physiological Functions, and Potential as Chemotherapeutic Targets.Molecules (Basel, Switzerland) · 2019Review
- Article
- Biochemistry of Mitochondrial Coenzyme Q Biosynthesis.Trends in biochemical sciences · 2017Review
- Human COQ9 Rescues aFrontiers in physiology · 2017Article
- Yeast Coq9 controls deamination of coenzyme Q intermediates that derive from para-aminobenzoic acid.Biochimica et biophysica acta · 2015Article
- Article
- The regulation of coenzyme q biosynthesis in eukaryotic cells: all that yeast can tell us.Molecular syndromology · 2014Article
- Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast coq null mutants.Biochimica et biophysica acta · 2014Article
- COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness.The Journal of clinical investigation · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Coenzyme Q is an isoprenylated benzoquinone lipid that functions in respiratory electron transport and as a lipid antioxidant. Dietary supplementation with Q is increasingly used as a therapeutic for treatment of mitochondrial and neurodegenerative diseases, yet little is known regarding the mechanism of its uptake. As opposed to other yeast backgrounds, EG103 strains are unable to import exogenous Q(6) to the mitochondria. Furthermore, the distribution of exogenous Q(6) among endomembranes suggests an impairment of the membrane traffic at the level of the endocytic pathway. This fact was confirmed after the detection of defects in the incorporation of FM4-64 marker and CPY delivery to the vacuole. A similar effect was demonstrated in double mutant strains in Q(6) synthesis and several steps of endocytic process; those cells are unable to uptake exogenous Q(6) to the mitochondria and restore the growth on non-fermentable carbon sources. Additional data about the positive effect of peptone presence for exogenous Q(6) uptake support the hypothesis that Q(6) is transported to mitochondria through an endocytic-based system.
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Registered trials
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