ArticleCurrent opinion in chemical biology2009
C-H bond activation in heme proteins: the role of thiolate ligation in cytochrome P450.
Article in Current opinion in chemical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
73 citing papers in PubMed, 182 citations in OpenAlex.
- Article
- Molecular Constraints and Electronic Structure Direct Multi-Step PCET Mechanisms in the Electrochemical Oxidation of Ruthenium Complexes.ACS omega · 2026Article
- Oxidizable amino acids around cytochrome P450 hemes.Journal of inorganic biochemistry · 2026Article
- Hole migration in cytochrome P450.QRB discovery · 2026Article
- Mechanistic Divergence in Sulfur-Ligated Iron(III)-Alkylperoxo Reactivity: Aldehyde Oxidation Prevails over Deformylation.Angewandte Chemie (International ed. in English) · 2025Article
- Intramolecular Oxo Atom Migration to theJournal of the American Chemical Society · 2025Article
- Insights into Active Site Cysteine Residues inInternational journal of molecular sciences · 2025Review
- Exploring the influence of H-bonding and ligand constraints on thiolate ligated non-heme iron mediated dioxygen activation.Chemical science · 2024Article
- Mechanism of the Oxidative Ring-Closure Reaction during Gliotoxin Biosynthesis by Cytochrome P450 GliF.International journal of molecular sciences · 2024Article
- Correlating Structure with Spectroscopy in Ascorbate Peroxidase Compound II.Journal of the American Chemical Society · 2024Article
- Influence of Equatorial Co-Ligands on the Reactivity of LFeMolecules (Basel, Switzerland) · 2023Article
- Improved Bioproduction of the Nylon 12 Monomer by Combining the Directed Evolution of P450 and Enhancing Heme Synthesis.Molecules (Basel, Switzerland) · 2023Article
- Biotransformation of Bisphenol by Human Cytochrome P450 2C9 Enzymes: A Density Functional Theory Study.Inorganic chemistry · 2023Article
- Construction of Biocatalysts Using the P450 Scaffold for the Synthesis of Indigo from Indole.International journal of molecular sciences · 2023Article
- Mechanism of Melatonin Metabolism by CYP1A1: What Determines the Bifurcation Pathways of Hydroxylation versus Deformylation?The journal of physical chemistry. B · 2022Article
- Electronic Structure and Reactivity of Dioxygen-Derived Aliphatic Thiolate-Ligated Fe-Peroxo and Fe(IV) Oxo Compounds.Journal of the American Chemical Society · 2022Article
- The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage.Frontiers in chemistry · 2022Article
- NRVS investigation of ascorbate peroxidase compound II: Observation of Iron(IV)oxo stretching.Journal of inorganic biochemistry · 2021Article
- Efficient Base-Free Aqueous Reforming of Methanol Homogeneously Catalyzed by Ruthenium Exhibiting a Remarkable Acceleration by Added Catalytic Thiol.Journal of the American Chemical Society · 2021Article
- Review
13 more citing papers are in PubMed but not listed here.
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The ability of cytochrome P450 to functionalize unactivated hydrocarbons at physiological temperature and pressure has attracted considerable interest from the chemical community. One of the more intriguing aspects of cytochrome P450 is the enzyme's use of a thiolate-ligated heme to perform demanding two-electron oxidations. This coordination is unusual, given that thiolate ligation can significantly decrease a heme reduction potential. In an effort to understand Nature's use of a donating thiolate in cytochrome P450, we have undertaken a systematic study of the high-valent forms of thiolate ligated heme proteins. Our investigations have revealed that the ferryl forms of these enzymes are basic. The basic ferryls afforded by thiolate ligation bias cytochrome P450 toward H-atom abstraction, creating an oxidant that cleaves CH bonds while avoiding unwanted oxidations of the protein superstructure. Recent synthetic work supports this hypothesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.