ReviewNeurobiology of learning and memory2009
Insights into a molecular switch that gates sensory neuron synapses during habituation in Aplysia.
Review in Neurobiology of learning and memory, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Anxiety and initial value dependence in startle habituation.Psychophysiology · 2022Article
- Brain-wide visual habituation networks in wild type and fmr1 zebrafish.Nature communications · 2022Article
- Excitatory postsynaptic calcium transients atLearning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Passive exposure attenuates distraction during visual search.Journal of experimental psychology. General · 2020Article
- A Review of Clinical Data on Salvage Therapy in Spinal Cord Stimulation.Neuromodulation : journal of the International Neuromodulation Society · 2020Review
- Habituation as a neural algorithm for online odor discrimination.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Distractor ignoring: strategies, learning, and passive filtering.Current directions in psychological science · 2019Article
- Treating Chronic Migraine With Neuromodulation: The Role of Neurophysiological Abnormalities and Maladaptive Plasticity.Frontiers in pharmacology · 2019Review
- The CaScientific reports · 2018Article
- Habituation of reflexive and motivated behavior in mice with deficient BK channel function.Frontiers in integrative neuroscience · 2013Article
- Release properties of individual presynaptic boutons expressed during homosynaptic depression and heterosynaptic facilitation of the Aplysia sensorimotor synapse.Frontiers in cellular neuroscience · 2013Article
- Article
- Auditory cortex lesions do not disrupt habituation of HPA axis responses to repeated noise stress.Brain research · 2012Article
- Evidence for a lack of phasic inhibitory properties of habituated stressors on HPA axis responses in rats.Physiology & behavior · 2012Article
- Article
- Molecular determinants of the spacing effect.Neural plasticity · 2012Review
- Group III metabotropic glutamate receptors inhibit startle-mediating giant neurons in the caudal pontine reticular nucleus but do not mediate synaptic depression/short-term habituation of startle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Long-term habituation of the gill-withdrawal reflex in aplysia requires gene transcription, calcineurin and L-type voltage-gated calcium channels.Frontiers in behavioral neuroscience · 2010Article
- Evolutionary conservation of the signaling proteins upstream of cyclic AMP-dependent kinase and protein kinase C in gastropod mollusks.Brain, behavior and evolution · 2009Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This review focuses on synaptic depression at sensory neuron-to-motor neuron synapses in the defensive withdrawal circuit of Aplysia as a model system for analysis of molecular mechanisms of sensory gating and habituation. We address the following topics: 1. Of various possible mechanisms that might underlie depression at these sensory neuron-to-motor neuron synapses in Aplysia, historically the most widely-accepted explanation has been depletion of the readily releasable pool of vesicles. Depletion is also believed to account for synaptic depression at long interstimulus intervals in a variety of other systems. 2. Multiple lines of evidence now indicate that vesicle depletion is not an important contributing mechanism to synaptic depression at Aplysia sensory neuron-to-motor neuron synapses. More generally, it appears that vesicle depletion does not contribute substantially to depression that occurs with those stimulus patterns that are typically used in studying behavioral habituation. 3. Recent evidence suggests that at these sensory neuron-to-motor neuron synapses in Aplysia, synaptic depression is mediated by an activity-dependent, but release-independent, switching of individual release sites to a silent state. This switching off of release sites is initiated by Ca2+ influx during individual action potentials. We discuss signaling proteins that may be regulated by Ca2+ during the silencing of release sites that underlies synaptic depression. 4. Bursts of 2-4 action potentials in presynaptic sensory neurons in Aplysia prevent the switching off of release sites via a mechanism called "burst-dependent protection" from synaptic depression. 5. This molecular switch may explain the sensory gating that allows animals to discriminate which stimuli are innocuous and appropriate to ignore and which stimuli are more important and should continue to elicit responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.