ArticleDevelopmental biology2009
Inactivation of Nxf2 causes defects in male meiosis and age-dependent depletion of spermatogonia.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene-disease relationships.Human reproduction update · 2021Pooled it
- NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis.Nature communications · 2025Article
- Searching for the 'X' factor: investigating the genetics of primary ovarian insufficiency.Journal of ovarian research · 2024Review
- A germline PAF1 paralog complex ensures cell type-specific gene expression.Genes & development · 2024Article
- Cancer testis antigens: Emerging therapeutic targets leveraging genomic instability in cancer.Molecular therapy. Oncology · 2024Review
- Lrh1 can help reprogram sexual cell fate and is required for Sertoli cell development and spermatogenesis in the mouse testis.PLoS genetics · 2022Article
- mRBPome capture identifies the RNA-binding protein TRIM71, an essential regulator of spermatogonial differentiation.Development (Cambridge, England) · 2020Article
- Toward Development of the Male Pill: A Decade of Potential Non-hormonal Contraceptive Targets.Frontiers in cell and developmental biology · 2020Review
- An RNA exporter that enforces a no-export policy.Nature structural & molecular biology · 2019Article
- The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.Nature structural & molecular biology · 2019Article
- DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions.Cell reports · 2018Article
- A novel TEX11 mutation induces azoospermia: a case report of infertile brothers and literature review.BMC medical genetics · 2018Review
- BRDT is an essential epigenetic regulator for proper chromatin organization, silencing of sex chromosomes and crossover formation in male meiosis.PLoS genetics · 2018Article
- Embryonic lethality and defective male germ cell development in mice lacking UTF1.Scientific reports · 2017Article
- Cancer/Testis genes in relation to sperm biology and function.Iranian journal of basic medical sciences · 2017Review
- Polycomb directs timely activation of germline genes in spermatogenesis.Genes & development · 2017Article
- Copy number gain of VCX, X-linked multi-copy gene, leads to cell proliferation and apoptosis during spermatogenesis.Oncotarget · 2016Article
- Cytoplasmic localization of SBR (Dm NXF1) protein and its zonal distribution in the ganglia of Drosophila melanogaster larvae.Invertebrate neuroscience : IN · 2016Article
- Ectopic Expression of Testis Germ Cell Proteins in Cancer and Its Potential Role in Genomic Instability.International journal of molecular sciences · 2016Review
- TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse.EMBO molecular medicine · 2015Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
In eukaryotes, mRNA is actively transported from nucleus to cytoplasm by a family of nuclear RNA export factors (NXF). While yeast harbors only one such factor (Mex67p), higher eukaryotes encode multiple NXFs. In mouse, four Nxf genes have been identified: Nxf1, Nxf2, Nxf3, and Nxf7. To date, the function of mouse Nxf genes has not been studied by targeted gene deletion in vivo. Here we report the generation of Nxf2 null mutant mice by homologous recombination in embryonic stem cells. Nxf2-deficient male mice exhibit fertility defects that differ between mouse strains. One third of Nxf2-deficient males on a mixed (C57BL/6x129) genetic background exhibit meiotic arrest and thus are sterile, whereas the remaining males are fertile. Disruption of Nxf2 in inbred (C57BL/6J) males impairs spermatogenesis, resulting in male subfertility, but causes no meiotic arrest. Testis weight and sperm output in C57BL/6J Nxf2(-/Y) mice are sharply reduced. Mutant epididymal sperm exhibit diminished motility. Importantly, proliferation of spermatogonia in Nxf2(-/Y) mice is significantly decreased. As a result, inactivation of Nxf2 causes depletion of germ cells in a substantial fraction of seminiferous tubules in aged mice. These studies demonstrate that Nxf2 plays a dual function in spermatogenesis: regulation of meiosis and maintenance of spermatogonial stem cells.
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