ArticleReproductive biology and endocrinology : RB&E2009
Expression of the calcium-activated potassium channel in upper and lower segment human myometrium during pregnancy and parturition.
Article in Reproductive biology and endocrinology : RB&E, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Utero-placental calcium and magnesium ion channels: A systematic review of obstetric implications of their alterations.Channels (Austin, Tex.) · 2026Pooled it
- Novel identification and modulation of the mechanosensitive Piezo1 channel in human myometrium.The Journal of physiology · 2023Article
- Differential Regulation by Mechanical Stretch of the Expressions of Large-Conductance CaThe Journal of membrane biology · 2022Article
- BKCa participates in E2 inducing endometrial adenocarcinoma by activating MEK/ERK pathway.BMC cancer · 2018Article
- BKCa channel regulates calcium oscillations induced by alpha-2-macroglobulin in human myometrial smooth muscle cells.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Expression of Potassium Channels in Uterine Smooth Muscle Cells from Patients with Adenomyosis.Chinese medical journal · 2016Article
- BK channels regulate myometrial contraction by modulating nuclear translocation of NF-κB.Endocrinology · 2014Article
- Hen uterine gene expression profiling during eggshell formation reveals putative proteins involved in the supply of minerals or in the shell mineralization process.BMC genomics · 2014Article
- Article
- Functional insights into modulation of BKCa channel activity to alter myometrial contractility.Frontiers in physiology · 2014Review
- Characterization of the myometrial transcriptome in women with an arrest of dilatation during labor.Journal of perinatal medicine · 2013Article
- TREK-1 currents in smooth muscle cells from pregnant human myometrium.American journal of physiology. Cell physiology · 2013Article
- Effects of progesterone treatment on expression of genes involved in uterine quiescence.Reproductive sciences (Thousand Oaks, Calif.) · 2011Article
- Expression of ATP-sensitive potassium channels in human pregnant myometrium.Reproductive biology and endocrinology : RB&E · 2011Article
- A molecular signature of an arrest of descent in human parturition.American journal of obstetrics and gynecology · 2011Article
- Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term.Journal of perinatal medicine · 2010Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLarge conductance calcium-activated potassium channel (BKCa) plays an important role in the control of uterine contractility during pregnancy. The change from uterine quiescence to enhanced contractile activity may be associated with the spatial and temporal expression of BKCa within myometrium. The objectives of this study were to examine the expression of BKCa alpha- and beta-subunit in upper segment (US) and lower segment (LS) regions of uterus, and to investigate for the possibly differential expression of these proteins in US and LS myometrium obtained from three functional states: (1) non-pregnant (NP); (2) term pregnant not in labour (TNL) and (3) term pregnant in labour (TL).
methodsMyometrial biopsies were collected from non-pregnant women at hysterectomy and pregnant women at either elective caesarean section or emergency caesarean section. Protein expression level and cellular localization of BKCa alpha- and beta-subunit in US and LS myometrium were determined by Western blot analysis and immunohistochemistry, respectively.
resultsBKCa alpha- and beta-subunit were predominantly localized to myometrial smooth muscle in both US and LS myometrium obtained from non-pregnant and pregnant patients. The level of BKCa alpha-subunit in US but not in LS was significantly higher in NP myometrium than those measured in myometrium obtained during pregnancy. Lower expression of BKCa alpha-subunit in both US and LS was found in TL than in TNL biopsies. Expression of beta-subunit in both US and LS myometrium was significantly reduced in TL group compared with those measured in TNL group. There was no significant difference in BKCa beta-subunit expression in either US or LS between NP and TNL group.
conclusionOur results suggest that expression of BKCa alpha- and beta-subunit in pregnant myometrium is reduced during labour, which is consistent with the myometrial activity at the onset of parturition.
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