ArticleEnvironmental health : a global access science source2009
Association of blood lead concentrations with mortality in older women: a prospective cohort study.
Article in Environmental health : a global access science source, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2018Pooled it
- Causal relationship between blood metal levels and breast cancer risk: a Mendelian randomization study in East Asian populations.Discover oncology · 2025Article
- Do we underestimate risk of cardiovascular mortality due to lead exposure?The Science of the total environment · 2024Article
- Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation andInternational journal of environmental research and public health · 2023Article
- Blood Lead Concentrations and Mortality in Korean Adults: the Korea National Health and Nutrition Examination Survey with Mortality Follow-Up.International journal of environmental research and public health · 2020Article
- Article
- Developing a Health Impact Model for Adult Lead Exposure and Cardiovascular Disease Mortality.Environmental health perspectives · 2020Article
- Interpretation of Population Health Metrics: Environmental Lead Exposure as Exemplary Case.Hypertension (Dallas, Tex. : 1979) · 2020Review
- Blood lead level risk factors and reference value derivation in a cross-sectional study of potentially lead-exposed workers in Iran.BMJ open · 2019Article
- Mortality risk reduction differs according to bisphosphonate class: a 15-year observational study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Observational
- Urinary Lead Concentration Is an Independent Predictor of Cancer Mortality in the U.S. General Population.Frontiers in oncology · 2018Article
- Accelerated bone loss and increased post-fracture mortality in elderly women and men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Lead Toxicity Risks in Gunshot Victims.PloS one · 2015Article
- A protocol for a systematic review of the effectiveness of interventions to reduce exposure to lead through consumer products and drinking water.Systematic reviews · 2014Article
- Synergistic effects of amyloid peptides and lead on human neuroblastoma cells.Cellular & molecular biology letters · 2012Article
- Whole blood lead levels are associated with biomarkers of joint tissue metabolism in African American and white men and women: the Johnston County Osteoarthritis Project.Environmental research · 2011Article
- The protean toxicities of lead: new chapters in a familiar story.International journal of environmental research and public health · 2011Review
- Whole blood lead levels are associated with radiographic and symptomatic knee osteoarthritis: a cross-sectional analysis in the Johnston County Osteoarthritis Project.Arthritis research & therapy · 2011Article
- Indicators of "healthy aging" in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival.BMC geriatrics · 2010Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundBlood lead concentrations have been associated with increased risk of cardiovascular, cancer, and all-cause mortality in adults in general population and occupational cohorts. We aimed to determine the association between blood lead, all cause and cause specific mortality in elderly, community residing women.
methodsProspective cohort study of 533 women aged 65-87 years enrolled in the Study of Osteoporotic Fractures at 2 US research centers (Baltimore, MD; Monongahela Valley, PA) from 1986-1988. Blood lead concentrations were determined by atomic absorption spectrometry. Using blood lead concentration categorized as < 8 microg/dL (0.384 micromol/L), and > or = 8 microg/dL (0.384 micromol/L), we determined the relative risk of mortality from all cause, and cause-specific mortality, through Cox proportional hazards regression analysis.
resultsMean blood lead concentration was 5.3 +/- 2.3 microg/dL (range 1-21) [0.25 +/- 0.11 micromol/L (range 0.05-1.008)]. After 12.0 +/- 3 years of > 95% complete follow-up, 123 (23%) women who died had slightly higher mean (+/- SD) blood lead 5.56 (+/- 3) microg/dL [0.27(+/- 0.14) micromol/L] than survivors: 5.17(+/- 2.0) [0.25(+/- 0.1) micromol/L] (p = 0.09). Women with blood lead concentrations > or = 8 microg/dL (0.384 micromol/L), had 59% increased risk of multivariate adjusted all cause mortality (Hazard Ratio [HR], 1.59; 95% confidence interval [CI], 1.02-2.49) (p = 0.041) especially coronary heart disease (CHD) mortality (HR = 3.08 [CI], (1.23-7.70)(p = 0.016), compared to women with blood lead concentrations < 8 microg/dL(< 0.384 mumol/L). There was no association of blood lead with stroke, cancer, or non cardiovascular deaths.
conclusionWomen with blood lead concentrations of > or = 8 microg/dL (0.384 micromol/L), experienced increased mortality, in particular from CHD as compared to those with lower blood lead concentrations.
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