Evidence map›Paper›PMID 19344423›Full record

ReviewBritish journal of haematology2009

Update in understanding common variable immunodeficiency disorders (CVIDs) and the management of patients with these conditions.

Helen Chapel, Charlotte Cunningham-Rundles

Open access · greenAbstract readReview
In one paragraph

Review in British journal of haematology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers.

0numbers the graph read from it
0cells of the map it votes in
160citing papers in PubMed
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

160 citing papers in PubMed, 388 citations in OpenAlex.

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  19. Autoimmunity in Primary Immunodeficiencies (PID).Clinical reviews in allergy & immunology · 2023
    Review
  20. Article

100 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Helen ChapelDepartment of Clinical Immunology, Oxford Radcliffe Hospitals, Oxford, UK. helen.chapel@ndm.ox.ac.uk
Charlotte Cunningham-Rundles
John Radcliffe Hospital · GBMount Sinai Medical Center · US

Funding

Regulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2004 to 2021
$29.8M
TARGETING PRIMARY IMMUNODEFICIENCY AMONG MINORITIESR18AI048693 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2000 to 2016
$6.2M
Exposporium determinants of Bacillus anthracisR21AI101093 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI STEWART, GEORGE C. · 2012 to 2013
$390k
NIAID NIH HHS AI 101093NIAID NIH HHS AI-467320NIAID NIH HHS AI-48693NIAID NIH HHS P01 AI061093NIAID NIH HHS R18 AI048693NIAID NIH HHS R21 AI101093
6 · The paper itself

Abstract

The common variable immunodeficiency disorders are a mixed group of heterogeneous conditions linked by lack of immunoglobulin production and primary antibody failure. This variability results in difficulty in making coherent sense of either immunopathogenesis or the role of various genetic abnormalities reported in the literature. The recent attempt to collate the varied complications in these conditions and to define particular clinical phenotypes has improved our understanding of these diseases. Once refined and confirmed by other studies, these definitions will facilitate improved accuracy of prognosis and better management of clinical complication. They may also provide a method of analysing outcomes as related to new immunopathological and genetic findings.

Indexed as

Age of OnsetCommon Variable ImmunodeficiencyHumansImmunoglobulin GImmunoglobulins, IntravenousPolymorphism, GeneticSurvival RateImmunoglobulin GImmunoglobulins, Intravenous

Identifiers

PMID19344423
PMCPMC2718064
OpenAlexW1995738251

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.