Trial reportMetabolic syndrome and related disorders2009
Interrelation between sex hormones and plasma sex hormone-binding globulin and hemoglobin A1c in healthy postmenopausal women.
Trial report in Metabolic syndrome and related disorders, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Association of hemoglobin levels with metabolic traits in women with PCOS.Acta obstetricia et gynecologica Scandinavica · 2025Article
- The relationship between sex hormones and glycated hemoglobin in a non-diabetic middle-aged and elderly population.BMC endocrine disorders · 2022Article
- A Nephrologist Perspective on Obesity: From Kidney Injury to Clinical Management.Frontiers in medicine · 2021Review
- The impact of androgen actions in neurons on metabolic health and disease.Molecular and cellular endocrinology · 2018Review
- Gender differences in glucose homeostasis and diabetes.Physiology & behavior · 2018Review
- Human sex hormone-binding globulin does not provide metabolic protection against diet-induced obesity and dysglycemia in mice.Endocrine connections · 2018Article
- Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications.Clinical science (London, England : 1979) · 2017Review
- Sex differences in the effects of androgens acting in the central nervous system on metabolism.Dialogues in clinical neuroscience · 2016Review
- Reactive oxygen species: players in the cardiovascular effects of testosterone.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Review
- Androgens, Bilateral Oophorectomy, and Cardiovascular Disease Mortality in Postmenopausal Women With and Without Diabetes: The Study of Osteoporotic Fractures.Diabetes care · 2015Observational
- The role of androgens in metabolism, obesity, and diabetes in males and females.Obesity (Silver Spring, Md.) · 2015Review
- Response: higher glycated hemoglobin level is associated with increased risk for ischemic stroke in non-diabetic korean male adults (diabetes metab j 2011;35:551-7).Diabetes & metabolism journal · 2012Article
- Sex hormone-binding globulin and type 2 diabetes mellitus.Trends in endocrinology and metabolism: TEM · 2012Review
- Higher glycated hemoglobin level is associated with increased risk for ischemic stroke in non-diabetic korean male adults.Diabetes & metabolism journal · 2011Article
- Gender differences in cardiovascular disease: hormonal and biochemical influences.Reproductive sciences (Thousand Oaks, Calif.) · 2010Review
- Testosterone, SHBG and cardiovascular health in postmenopausal women.International journal of impotence researchReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundAndrogenicity, as measured by low sex hormone-binding globulin (SHBG) and elevations in testosterone and free androgen index (FAI), is associated with adverse cardiovascular (CV) outcomes, possibly due to effects on insulin resistance and glycemia.
methodsGlycosylated hemoglobin (HbA1c) concentration, SHBG, and sex hormones were available in 200 nondiabetic postmenopausal women who were not using hormone therapy (HT) in the Women's Health Study. Of these, 98 were cardiovascular disease (CVD) cases; the remainders were matched controls. To achieve normality, continuous values were log transformed and geometric means were calculated. Associations between sex hormones and HbA1c were examined using general linear models (GLM), partial correlations, and multiple linear regression analyses.
resultsLower SHBG levels and higher FAI and HbA1c values were found among the CVD cases, and all analyses were adjusted for this factor. In GLM, higher values of HbA1c were observed in the highest quartiles of FAI and the lowest quartiles of SHBG. However, the correlation between SHBG and HbA1c across quartiles was eliminated after adjusting for body mass index (BMI). In partial correlations, HbA1c values were inversely associated with SHBG (r = -0.19, P = 0.008) and positively associated with FAI (r = 0.19, P = 0.01), even after adjusting for age, CVD case-control status, and BMI. In multivariate models, a significant inverse association between SHBG and HbA1c persisted, as well as a significant positive association between FAI and HbA1c.
conclusionsAndrogenicity, as measured by low SHBG and high FAI, is associated with glycemia, and thereby may contribute to CVD risk in postmenopausal women.
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