ReviewJournal of opioid management
The opioid-exposed newborn: assessment and pharmacologic management.
Review in Journal of opioid management. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01958476 (Improving Outcomes in Neonatal Abstinence Syndrome), which is not on this map. Cited by 103 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Outcomes in Neonatal Abstinence Syndrome
Who cites it
103 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Acupuncture for neonatal abstinence syndrome in newborn infants.The Cochrane database of systematic reviews · 2025Pooled it
- Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders.The Cochrane database of systematic reviews · 2020Pooled it
- Guideline
- Review of the assessment and management of neonatal abstinence syndrome.Addiction science & clinical practice · 2014Pooled it
- Telehealth delivery of modified attachment and biobehavioral catch-up: feasibility, acceptability, and lessons learned.Attachment & human development · 2023Trial
- Comparison of Safety and Efficacy of Methadone vs Morphine for Treatment of Neonatal Abstinence Syndrome: A Randomized Clinical Trial.JAMA pediatrics · 2018Trial
- Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study.The Journal of pediatrics · 2015Trial
- Auricular acupuncture for chemically dependent pregnant women: a randomized controlled trial of the NADA protocol.Substance abuse treatment, prevention, and policy · 2012Trial
- Neonatal neurobehavior effects following buprenorphine versus methadone exposure.Addiction (Abingdon, England) · 2012Trial
- Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonates.Addiction (Abingdon, England) · 2012Trial
- Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome.Addiction (Abingdon, England) · 2011Trial
- Neonatal abstinence syndrome after methadone or buprenorphine exposure.The New England journal of medicine · 2010Trial
- Physiologic dysregulation in newborns with prenatal opioid exposure: Cardiac, respiratory and movement activity.Neurotoxicology and teratologyTrial
- DNA Methylation of Neurodevelopmental, Stress-Response, Reward, and Opioid Pathway Genes: Sex Differences in Infants with Neonatal Opioid Exposure.medRxiv : the preprint server for health sciences · 2026Article
- Stochastic vibration and early weight growth in opioid-exposed newborns: a randomized trial.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Analgosedation in Neonatal Intensive Care: Current Strategies, Challenges, and Future Perspectives.Life (Basel, Switzerland) · 2026Review
- Early pharmacotherapy versus no pharmacotherapy: difference in skin conductance response to physical stimuli in infants with neonatal opioid withdrawal syndrome.BMC pediatrics · 2026Observational
- A Scoping Review of Non-Opioid Therapeutics for Opioid Withdrawal: Translational Relevance to Neonatal Opioid Withdrawal Syndrome (NOWS) Research.Clinical and translational science · 2026Article
- La prise en charge des nouveau-nés à risque de syndrome d'abstinence néonatale et de syndrome de sevrage néonatal aux opioïdes : mises à jour et pratiques exemplaires émergentes.Paediatrics & child health · 2025Review
- Managing newborns at risk for neonatal abstinence syndrome (NAS)/neonatal opioid withdrawal syndrome (NOWS): Updates and emerging best practices.Paediatrics & child health · 2025Review
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The infant exposed to opioids in utero frequently presents a challenge to the neonatal care provider in the assessment and treatment of symptoms of Neonatal Abstinence Syndrome (NAS) after birth. This review is intended to provide the healthcare professional with a brief review of current evidence and practical guidelines for optimal evaluation and pharmacologic management of the opioid-exposed newborn.
Indexed as
Identifiers
19344048PMC2729086What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.