ArticleIntensive care medicine2009
Predictors of bacteraemia and mortality in patients with acute liver failure.
Article in Intensive care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 102 citations in OpenAlex.
- Role of procalcitonin in identifying systemic inflammatory response syndrome and sepsis in acute-on-chronic liver failure and its impact on survival.BMC gastroenterology · 2025Article
- Sepsis in liver failure patients: Diagnostic challenges and recent advancements.World journal of critical care medicine · 2025Review
- Infection, inflammation and hepatic encephalopathy from a clinical perspective.Metabolic brain disease · 2024Review
- Diagnosis and management of pediatric acute liver failure: consensus recommendations of the Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ISPGHAN).Hepatology international · 2024Review
- Acute liver failure: A practical update.JHEP reports : innovation in hepatology · 2024Review
- Macrophage activation markers are associated with infection and mortality in patients with acute liver failure.Liver international : official journal of the International Association for the Study of the Liver · 2024Article
- Overview of acute liver failure in India.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- Review
- Article
- Susceptibility to Infections During Acute Liver Injury Depends on Transient Disruption of Liver Macrophage Niche.Frontiers in immunology · 2022Article
- Antibiotic prophylaxis in patients with cirrhosis: Current evidence for clinical practice.World journal of hepatology · 2021Review
- Perspective of placenta derived mesenchymal stem cells in acute liver failure.Cell & bioscience · 2020Review
- Liver maximum capacity (LiMAx) test as a helpful prognostic tool in acute liver failure with sepsis: a case report.BMC anesthesiology · 2018Article
- The Role of Monocytes and Macrophages in Acute and Acute-on-Chronic Liver Failure.Frontiers in immunology · 2018Review
- Prognostic significance of infections in critically ill adult patients with acute liver injury: a retrospective cohort study.Liver international : official journal of the International Association for the Study of the Liver · 2016Article
- Role of inflammation and infection in the pathogenesis of human acute liver failure: Clinical implications for monitoring and therapy.World journal of gastroenterology · 2016Review
- Improved prescription of taohechengqi-tang alleviates D-galactosamine acute liver failure in rats.World journal of gastroenterology · 2016Article
- Gender and ethnic differences in the post-liver transplant outcomes of patients with autoimmune hepatitis with acute liver failure at initial presentation: a case-control study.Archives of medical science : AMS · 2015Article
- Surveillance for infectious complications in pediatric acute liver failure - a prospective study.Indian journal of pediatrics · 2015Article
- Antibiotics in Acute Liver Failure (ALF).Journal of clinical and experimental hepatology · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine what physiological and biochemical factors predict development of bacteraemia and mortality in patients with acute liver failure (ALF).
methodsRetrospective analysis of 206 ALF patients admitted to a specialist liver intensive therapy unit (LITU) from January 2003 to July 2005 (data collected prospectively).
resultsA total of 206 patients were defined with ALF: 72 (35%) suffered bacteraemia (BAClf) and 134 (65%) did not (NBAClf). Gram positive organisms were observed in 44% of isolates, gram negatives in 52% and fungaemia in 4%. Median time to first bacteraemia was 10 (7-16) days. On admission, BAClf patients had higher SIRS scores and degrees of hepatic encephalopathy (HE). During their LITU course, BAClf patients had significantly increased requirements for renal replacement therapy (RRT), mechanical ventilation, and longer median LITU stay. Multivariate analysis (logistical regression) demonstrated significant predictors of bacteraemia on admission were HE grade >2 (Odds Ratio 1.6) and SIRS score >1 (OR 2.7). In all patients, independent predictors of mortality (logistical) were age (OR 1.41), maximum HE grade pre-intubation (1.76), Lactate (1.14) and Acute Physiology and Chronic Health Evaluation II score (APACHEII) (1.09), but not bacteraemia. Transplantation was protective (OR 0.20).
conclusionIn this study, severity of hepatic encephalopathy and SIRS score >1 were predictive of bacteraemia. APACHEII was independently predictive of mortality in all ALF patients but not bacteraemia.
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