ReviewWiener medizinische Wochenschrift (1946)2009
Homology modelling: a review about the method on hand of the diabetic antigen GAD 65 structure prediction.
Review in Wiener medizinische Wochenschrift (1946), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Space constrained homology modelling: the paradigm of the RNA-dependent RNA polymerase of dengue (type II) virus.Computational and mathematical methods in medicine · 2013Article
- Dynamic changes in the secondary structure of ECE-1 and XCE account for their different substrate specificities.BMC bioinformatics · 2012Article
- [Diabetes mellitus].Wiener medizinische Wochenschrift (1946) · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This introductory paper describes the basic principles and clinical applications of the protein 3D structure prediction by homology modelling. The paper mainly addresses physicians and medical chemists. Because many proteins are of immediate clinical importance, the determination of their structures is crucial for molecular medicine. In homology modelling, a protein sequence with unknown structure is aligned with sequences of known protein structures. By exploiting structural information from the known configurations, the new structure can be predicted. The necessary condition for successful homology modelling is a sufficient similarity between the protein sequences. Because in the near future for every protein family at least one member with a known structure will be available, the importance and applicability of homology modelling is steadily increasing. We demonstrate the principles of homology modelling on hand of the Glutamic Acid Decarboxylase (GAD 65) structure prediction, which is a typical autoantigen involved in Diabetes Mellitus Type 1.
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