ArticleMediators of inflammation2009
The interaction of oxidative stress response with cytokines in the thyrotoxic rat: is there a link?
Article in Mediators of inflammation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Another pleiotropic effect of SGLT2 inhibitors: Is it a new frontier in thyroid function regulation?Thyroid research · 2026Review
- SGLT2 inhibitor as a potential therapeutic approach in hyperthyroidism-induced cardiopulmonary injury in rats.Pflugers Archiv : European journal of physiology · 2024Article
- Impact of carbimazole combined with vitamin E on testicular injury induced by experimental hyperthyroidism in adult albino rats: oxidative/inflammatory/apoptotic pathways.Asian journal of andrology · 2024Article
- The role of autophagy in Graves disease: knowns and unknowns.Frontiers in cell and developmental biology · 2024Review
- Protective role of vitamin D3 in a rat model of hyperthyroid-induced cardiomyopathy.Journal of traditional and complementary medicine · 2023Article
- Chavibetol corrects thyrotoxicosis through alterations in thyroid peroxidase.Naunyn-Schmiedeberg's archives of pharmacology · 2019Article
- Evaluation of the Relationship Between Ischemia-Modified Albumin Levels and Thyroid Hormone Levels.Journal of clinical laboratory analysis · 2015Article
- A study of serum malondialdehyde and cytokine in tuberculosis patients.Journal of clinical and diagnostic research : JCDR · 2013Article
- The role of thyroid hormones as inductors of oxidative stress and neurodegeneration.Oxidative medicine and cellular longevity · 2013Review
- Status of proinflammatory and anti-inflammatory cytokines in different brain regions of a rat model of Japanese encephalitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- The role of oxidative stress on the pathogenesis of graves' disease.Journal of thyroid research · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress is regarded as a pathogenic factor in hyperthyroidism. Our purpose was to determine the relationship between the oxidative stress and the inflammatory cytokines and to investigate how melatonin affects oxidative damage and cytokine response in thyrotoxic rats. Twenty-one rats were divided into three groups. Group A served as negative controls. Group B had untreated thyrotoxicosis, and Group C received melatonin. Serum malondialdehyde (MDA), glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), and nitric oxide derivates (NO*x), and plasma IL-6, IL-10, and TNF-alpha were measured. MDA, GSH, NO*x, IL-10, and TNF-alpha levels increased after L-thyroxine induction. An inhibition of triiodothyronine and thyroxine was detected, as a result of melatonin administration. MDA, GSH, and NO*x levels were also affected by melatonin. Lowest TNF-alpha levels were observed in Group C. This study demonstrates that oxidative stress is related to cytokine response in the thyrotoxic rat. Melatonin treatment suppresses the hyperthyroidism-induced oxidative damage as well as TNF-alpha response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.