ArticleGastrointestinal cancer research : GCR2008
Emerging molecular biology of pancreatic cancer.
Article in Gastrointestinal cancer research : GCR, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Review
- Circulating tumour DNA: a challenging innovation to develop "precision onco-surgery" in pancreatic adenocarcinoma.British journal of cancer · 2022Review
- Review
- MicroRNA-125a inhibits tumorigenesis by targeting Smurf1 in colorectal carcinoma.FEBS open bio · 2019Article
- Cadherin-1 and cadherin-3 cooperation determines the aggressiveness of pancreatic ductal adenocarcinoma.British journal of cancer · 2018Article
- Diabetes Type 2 and Pancreatic Cancer: A History Unfolding.JOP : Journal of the pancreas · 2016Article
- PHLPP negatively regulates cell motility through inhibition of Akt activity and integrin expression in pancreatic cancer cells.Oncotarget · 2016Article
- Pancreatic cancer: optimizing treatment options, new, and emerging targeted therapies.Drug design, development and therapy · 2015Review
- Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis.PloS one · 2014Article
- Requirement of NEMO/IKKγ for effective expansion of KRAS-induced precancerous lesions in the pancreas.Oncogene · 2013Article
- Gene therapy of pancreatic cancer targeting the K-Ras oncogene.Cancer gene therapy · 2012Article
- Aberrant signaling pathways in pancreatic cancer: a two compartment view.Molecular carcinogenesis · 2012Article
- Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis.Cancer research · 2011Article
- Article
- Familial pancreatic cancer.Cancers · 2010Article
- Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity.Cancer research · 2010Article
- Targeted therapies for pancreatic cancer.Gastrointestinal cancer research : GCR · 2008Article
- Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts.The Journal of molecular diagnostics : JMD · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancreatic cancer, like most other cancers, is fundamentally caused by mutations in specific genes. Many of the genes targeted in pancreatic cancer have been identified in the past decade, and an understanding of these genes and their function has helped identify familial forms of pancreatic cancer, define the precursor lesions from which invasive pancreatic cancers arise, and will soon lead to gene-specific therapies for this disease. This article reviews the tumor-suppressor genes, oncogenes, and DNA repair genes targeted in pancreatic cancer, and presents clinical applications based on our understanding of the genetic basis of pancreatic cancer.
Identifiers
19343140PMC2661541W2398619901What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.