ArticleDose-response : a publication of International Hormesis Society2009
A perspective on the scientific, philosophical, and policy dimensions of hormesis.
Article in Dose-response : a publication of International Hormesis Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
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- Thick or Thin? Implications of Cartilage Architecture for Osteoarthritis Risk in Sedentary Lifestyles.Biomedicines · 2025Review
- Low-Dose Ionizing Radiation Exposure on Human Male Gametes: Damage or Benefit.Life (Basel, Switzerland) · 2024Review
- Methylglyoxal in Cardiometabolic Disorders: Routes Leading to Pathology Counterbalanced by Treatment Strategies.Molecules (Basel, Switzerland) · 2023Review
- PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer's Disease.Current neuropharmacology · 2022Review
- Reconceptualization of Hormetic Responses in the Frame of Redox Toxicology.International journal of molecular sciences · 2021Review
- Combined effects of alpha particles and depleted uranium on Zebrafish (Danio rerio) embryos.Journal of radiation research · 2016Article
- Cadmium Protection Strategies--A Hidden Trade-Off?International journal of molecular sciences · 2016Review
- New considerations on hormetic response against oxidative stress.Journal of cell communication and signaling · 2014Article
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- The antimicrobial activity of lapachol and its thiosemicarbazone and semicarbazone derivatives.Memorias do Instituto Oswaldo Cruz · 2013Article
- Hurdles to clear before clinical translation of ischemic postconditioning against stroke.Translational stroke research · 2013Review
- Using hormetic strategies to improve ischemic preconditioning and postconditioning against stroke.International journal of physiology, pathophysiology and pharmacology · 2013Article
- Cognitive activation by central thalamic stimulation: the yerkes-dodson law revisited.Dose-response : a publication of International Hormesis Society · 2011Article
- Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders.Antioxidants & redox signaling · 2010Review
- Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples.Archives of toxicology · 2010Review
- Radiation hormesis: historical perspective and implications for low-dose cancer risk assessment.Dose-response : a publication of International Hormesis Society · 2010Article
- Hormesis, adaptive epigenetic reorganization, and implications for human health and longevity.Dose-response : a publication of International Hormesis Society · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hormesis concept has broad implications for biology and the biomedical sciences. This perspective on hormesis concentrates on toxicology and toxicological risk assessment and secondarily explores observations from other fields. It considers the varied manifestations of hormesis in the context of a broad family of biological stress responses. Evidence for hormesis is reviewed, and the hormesis model is contrasted with more widely accepted dose-response models in toxicology: a linear nonthreshold (LNT) model for mutagenesis and carcinogenesis, and a threshold model for most other toxicologic effects. Scientific, philosophical, and political objections to the hormesis concept are explored, and complications in the hormesis concept are analyzed. The review concludes with a perspective on the current state of hormesis and challenges that the hormesis model poses for risk assessment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.