ArticleEMBO reports2009
ARGONAUTE 1 homeostasis invokes the coordinate action of the microRNA and siRNA pathways.
Article in EMBO reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 98 citations in OpenAlex.
- Oxidative stress: a new player in the regulation of AGO1 homeostasis?Journal of experimental botany · 2025Article
- Response to "The action of Arabidopsis DICER-LIKE2 in plant growth inhibition".The Plant cell · 2025Article
- Transcriptome, miRNA, and degradome sequencing reveal the leaf stripe (Pyrenophora graminea) resistance genes in Tibetan hulless barley.BMC plant biology · 2025Article
- The Use of Arabidopsis thaliana to Characterize the Production and Action Stages of the Plant MicroRNA Pathway.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Quantitative Investigation ofInternational journal of molecular sciences · 2023Article
- Induction of Somatic Embryogenesis in Plants: Different Players and Focus on WUSCHEL and WUS-RELATED HOMEOBOX (WOX) Transcription Factors.International journal of molecular sciences · 2022Review
- Controlled RISC loading efficiency of miR168 defined by miRNA duplex structure adjusts ARGONAUTE1 homeostasis.Nucleic acids research · 2021Article
- Non-Coding RNAs in Response to Drought Stress.International journal of molecular sciences · 2021Review
- Atypical molecular features of RNA silencing against the phloem-restricted polerovirus TuYV.Nucleic acids research · 2021Article
- A new method for functional analysis of plastid EMBRYO-DEFECTIVE PPR genes by efficiently constructing cosuppression lines in Arabidopsis.Plant methods · 2020Article
- Features of sRNA biogenesis in rice revealed by genetic dissection of sRNA expression level.Computational and structural biotechnology journal · 2020Article
- Genome-scale, single-cell-type resolution of microRNA activities within a whole plant organ.The EMBO journal · 2019Article
- Assessing the Response of Small RNA Populations to Allopolyploidy Using Resynthesized Brassica napus Allotetraploids.Molecular biology and evolution · 2019Article
- A Small RNA-Mediated Regulatory Network inFrontiers in plant science · 2019Article
- Article
- A Short Indel-Lacking-Resistance Gene Triggers Silencing of the Photosynthetic Machinery Components Through TYLCSV-Associated Endogenous siRNAs in Tomato.Frontiers in plant science · 2018Article
- A Genetic Screen for Impaired Systemic RNAi Highlights the Crucial Role of DICER-LIKE 2.Plant physiology · 2017Article
- Integrated analysis of tobacco miRNA and mRNA expression profiles under PVY infection provids insight into tobacco-PVY interactions.Scientific reports · 2017Article
- Abscisic Acid Induces Resistance againstPlant physiology · 2017Article
- MicroRNAs Are Intensively Regulated during Induction of Somatic Embryogenesis in Arabidopsis.Frontiers in plant science · 2017Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ARGONAUTE 1 (AGO1) slices endogenous messenger RNAs (mRNAs) during both microRNA (miRNA)- and short interfering RNA (siRNA)-guided post-transcriptional silencing. We have previously reported that AGO1 homeostasis is maintained through the repressive action of miR168 on AGO1 mRNA and the stabilizing effect of AGO1 protein on miR168, but siRNA-mediated AGO1 regulation has not been reported. Here, we show that AGO1-derived siRNAs trigger RNA DEPENDENT RNA POLYMERASE 6 (RDR6)-, SUPPRESSOR OF GENE SILENCING 3 (SGS3)- and SILENCING DEFECTIVE 5 (SDE5)-dependent AGO1 silencing, which also requires DICER-LIKE 2 (DCL2) and DCL4. By varying the efficacy of miR168-guided AGO1 mRNA cleavage, we show that siRNA-mediated AGO1 silencing depends on correct miRNA targeting, pointing to coordinated regulatory actions of the miRNA and siRNA pathways during the maintenance of AGO1 homeostasis. Finally, our results reveal that dcl2, dcl3 and dcl4 mutations similarly affect post-transcriptional gene silencing (PTGS) mediated by a sense transgene and PTGS mediated by inverted repeats, validating the branched pathway model proposed previously.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.