ArticleThe American journal of gastroenterology2009
Editorial: Defining a bad Barrett's segment: is it dependent on goblet cells?
Article in The American journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Histology of Barrett's Metaplasia: Do Goblet Cells Matter?Digestive diseases and sciences · 2018Review
- Carcinogenesis of Barrett's esophagus: a review of the clinical literature.Clinical journal of gastroenterology · 2013Article
- Diagnosis and management of Barrett's metaplasia: What's new.World journal of gastrointestinal endoscopy · 2012Article
- Math1/Atoh1 contributes to intestinalization of esophageal keratinocytes by inducing the expression of Muc2 and Keratin-20.Digestive diseases and sciences · 2012Article
- Confocal Laser Endomicroscopy for Diagnosis of Barrett's Esophagus.Frontiers in oncology · 2012Article
Corrections and comments
- Comment on
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of patients with "bad Barrett's" who are at risk of neoplastic progression is a vital and pressing task. The view that specialized intestinal metaplasia with goblet cells is the predominant preneoplastic phenotype has had wide, but by no means universal, acceptance. An important caveat is presented in the thoughtful paper by Liu et al. in this issue. Of 68 patients with columnar metaplasia, 22 patients had no goblet cells identified and 46 had goblet cells in their biopsies. In both groups there were chromosomal and DNA content abnormalities and genetic instability. However, there were no significant differences between these cellular DNA abnormalities in the two groups. Both were significantly different from gastric controls. Thus, all metaplasia in the columnar-lined esophagus may already be on the path to cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.