ReviewJournal of andrology
Posttranslational modification of constitutive nitric oxide synthase in the penis.
Review in Journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Adipose tissue-derived stem cell therapy for erectile dysfunction in rats: a systematic review and meta-analysis.International urology and nephrology · 2017Pooled it
- Nitric oxide synthase and its function in animal reproduction: an update.Frontiers in physiology · 2023Review
- Alterations in the phosphodiesterase type 5 pathway and oxidative stress correlate with erectile function in spontaneously hypertensive rats.Journal of cellular and molecular medicine · 2020Article
- Clinical and Genetic Predictors of Priapism in Sickle Cell Disease: Results from the Recipient Epidemiology and Donor Evaluation Study III Brazil Cohort Study.The journal of sexual medicine · 2019Article
- Epalrestat, an Aldose Reductase Inhibitor, Restores Erectile Function in Streptozocin-induced Diabetic Rats.International journal of impotence research · 2019Article
- Icariside II Promotes the Differentiation of Adipose Tissue-Derived Stem Cells to Schwann Cells to Preserve Erectile Function after Cavernous Nerve Injury.Molecules and cells · 2018Article
- Neuronal Voltage Gated Potassium Channels May Modulate Nitric Oxide Synthesis in Corpus Cavernosum.Frontiers in pharmacology · 2017Article
- Molecular and functional characterization of Kv 7 channels in penile arteries and corpus cavernosum of healthy and metabolic syndrome rats.British journal of pharmacology · 2016Article
- Effect of acute lithium administration on penile erection: involvement of nitric oxide system.International journal of reproductive biomedicine · 2016Article
- Nitrergic Mechanisms for Management of Recurrent Priapism.Sexual medicine reviews · 2015Article
- Gas what: NO is not the only answer to sexual function.British journal of pharmacology · 2015Review
- Molecular pathophysiology of priapism: emerging targets.Current drug targets · 2015Review
- Effects of Icariside II on corpus cavernosum and major pelvic ganglion neuropathy in streptozotocin-induced diabetic rats.International journal of molecular sciences · 2014Article
- Nitric oxide synthase: non-canonical expression patterns.Frontiers in immunology · 2014Review
- Androgen depletion in humans leads to cavernous tissue reorganization and upregulation of Sirt1-eNOS axis.Age (Dordrecht, Netherlands) · 2013Article
- Molecular analysis of erection regulatory factors in sickle cell disease associated priapism in the human penis.The Journal of urology · 2013Article
- Preserved fertility despite erectile dysfunction in mice lacking the nitric oxide receptor.The Journal of physiology · 2013Article
- Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function.PloS one · 2013Article
- Article
- Post-translational inactivation of endothelial nitric oxide synthase in the transgenic sickle cell mouse penis.The journal of sexual medicine · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Erectile dysfunction (ED) is a common men's health problem characterized by the consistent inability to sustain an erection sufficient for sexual intercourse. Basic science research on erectile physiology has been devoted to investigating the pathogenesis of ED and has led to the conclusion that ED is predominately a disease of vascular origin, neurogenic dysfunction, or both. The constitutive forms of nitric oxide synthase (NOS, endothelial [eNOS] and neuronal [nNOS]) are important enzymes involved in the production of nitric oxide (NO) and thus regulate penile vascular homeostasis. Given the effect of endothelial- and neuronal-derived NO in penile vascular biology, a great deal of research over the past decade has focused on the role of NO synthesis from the endothelium and nitrergic nerve terminal in normal erectile physiology, as well as in disease states. Loss of the functional integrity of the endothelium and subsequent endothelial dysfunction plays an integral role in the occurrence of ED. Therefore, molecular mechanisms involved in dysregulation of these NOS isoforms in the development of ED are essential to discovering the pathogenesis of ED in various disease states. This communication reviews the role of eNOS and nNOS in erectile physiology and discusses the alterations in eNOS and nNOS via posttranslation modification in various vascular diseases of the penis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.