ArticleJournal of immunology (Baltimore, Md. : 1950)2009
A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 68 citations in OpenAlex.
- The Complement System and Its Role in Eosinophilic Inflammation in Respiratory Diseases.Biomedicines · 2026Review
- Complement's involvement in allergic Th2 immunity: a cross-barrier perspective.The Journal of clinical investigation · 2025Review
- The Value of Targeting Complement Components in Asthma.Medicina (Kaunas, Lithuania) · 2020Article
- Article
- Complement factor C5 inhibition reduces type 2 responses without affecting group 2 innate lymphoid cells in a house dust mite induced murine asthma model.Respiratory research · 2019Article
- Altered Peripheral Blood Leucocyte Phenotype and Responses in Healthy Individuals with Homozygous Deletion of FHR1 and FHR3 Genes.Journal of clinical immunology · 2019Article
- C3a receptor antagonism as a novel therapeutic target for chronic rhinosinusitis.Mucosal immunology · 2018Article
- Mesenchymal stem cells alleviate acute kidney injury by down-regulating C5a/C5aR pathway activation.International urology and nephrology · 2018Article
- The C5a/C5aR1 axis controls the development of experimental allergic asthma independent of LysM-expressing pulmonary immune cells.PloS one · 2017Article
- Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase.PloS one · 2017Article
- Targeted complement inhibition and microvasculature in transplants: a therapeutic perspective.Clinical and experimental immunology · 2016Review
- Origin, Localization, and Immunoregulatory Properties of Pulmonary Phagocytes in Allergic Asthma.Frontiers in immunology · 2016Review
- Properdin Contributes to Allergic Airway Inflammation through Local C3a Generation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Complement components as potential therapeutic targets for asthma treatment.Respiratory medicine · 2014Review
- Complement mediates a primed inflammatory response after traumatic lung injury.The journal of trauma and acute care surgery · 2014Article
- Molecular basis for downregulation of C5a-mediated inflammation by IgG1 immune complexes in allergy and asthma.Current allergy and asthma reports · 2013Review
- Epigenetic alterations by DNA methylation in house dust mite-induced airway hyperresponsiveness.American journal of respiratory cell and molecular biology · 2013Article
- Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases.The Journal of allergy and clinical immunology · 2013Review
- Adam8 limits the development of allergic airway inflammation in mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
The role of complement in the development of maladaptive immunity in experimental allergic asthma is unclear. In this study, we show that C3a receptor (C3aR)-deficient mice are protected from the development of Th2 immunity in a model of house dust mite-induced asthma. C5a receptor (C5aR)-targeting of C3aR-deficient mice during allergen sensitization not only reversed the protective effect but enhanced Th2 cytokine production, airway inflammation, and airway responsiveness, suggesting that the reduced allergic phenotype in C3aR-deficient mice results from protective C5aR signaling. In support of this view, C5aR expression in C3aR-deficient pulmonary dendritic cells (DCs) was increased when compared with wild-type DCs. Moreover, C5aR targeting regulated the frequency of pulmonary plasmacytoid DCs expressing costimulatory molecules B7-H1 and B7-DC. Ex vivo targeting of B7-H1 and B7-DC increased Th2 cytokine production from T cells of wild-type but not of C5aR-targeted mice, suggesting a protective role for C5a through regulation of B7 molecule expression on plasmacytoid DCs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.