ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- CD80 as an Important Immune Mediator and Therapeutic Target in Atherosclerosis.International journal of molecular sciences · 2026Review
- Blocking the innate immune CD1d/NKT cell axis prevents the development of cortical hyperexcitability and posttraumatic epilepsy.Epilepsia · 2025Article
- The cholesterol pathway: impact on immunity and cancer.Trends in immunology · 2022Review
- Therapeutic Effect of Bilsaan,Oxidative medicine and cellular longevity · 2020Article
- Atorvastatin increases the production of proinflammatory cytokines and decreases the survival of Escherichia coli-infected mice.Scientific reports · 2019Article
- Inhibition of CD1d-mediated antigen presentation by the transforming growth factor-β/Smad signalling pathway.Immunology · 2014Article
- Immune mechanisms in atherosclerosis, especially in diabetes type 2.Frontiers in endocrinology · 2013Review
- Forming a complex with MHC class I molecules interferes with mouse CD1d functional expression.PloS one · 2013Article
- Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Anthrax lethal toxin impairs CD1d-mediated antigen presentation by targeting the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway.Infection and immunity · 2010Article
- Therapeutic implications of statins beyond lipid lowering: In the perspective of their effects on the antigen presentation, T cells and NKT cells.International journal of health sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Statins are widely used as cholesterol-lowering agents that also decrease inflammation and target enzymes essential for prenylation, an important process in the activation and intracellular transport of proteins vital for a wide variety of cellular functions. Here, we report that statins impair a critical component of the innate immune response, CD1d-mediated Ag presentation. The addition of specific intermediates in the isoprenylation pathway reversed this effect, whereas specific targeting of enzymes responsible for prenylation mimicked the inhibitory effects of statins on Ag presentation by CD1d as well as MHC class II molecules. This study demonstrates the importance of isoprenylation in the regulation of Ag presentation and suggests a mechanism by which statins reduce inflammatory responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.