ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Tumor recognition and self-recognition induce distinct transcriptional profiles in antigen-specific CD4 T cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Rat and fish peripheral blood leukocytes respond distinctively toFrontiers in cellular and infection microbiology · 2022Article
- Role of ubiquitin specific proteases in the immune microenvironment of prostate cancer: A new direction.Frontiers in oncology · 2022Review
- Targeting the spectrum of immune checkpoints in prostate cancer.Expert review of clinical pharmacology · 2021Review
- Prostate Cancer Immunotherapy-Finally in From the Cold?Current oncology reports · 2021Review
- Revisiting Immunotherapy: A Focus on Prostate Cancer.Cancer research · 2020Review
- Emerging Functions of Regulatory T Cells in Tissue Homeostasis.Frontiers in immunology · 2018Review
- Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.Immunology · 2016Article
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- Cancer and the Immune System: Basic Concepts and Targets for Intervention.Seminars in oncology · 2015Review
- Shaping the repertoire of tumor-infiltrating effector and regulatory T cells.Immunological reviews · 2014Review
- Development of a peptide-based vaccine targeting TMPRSS2:ERG fusion-positive prostate cancer.Cancer immunology, immunotherapy : CII · 2013Article
- Sequencing CTLA-4 blockade with cell-based immunotherapy for prostate cancer.Journal of translational medicine · 2013Article
- Genetically engineered mouse models of cancer reveal new insights about the antitumor immune response.Current opinion in immunology · 2013Review
- Convergences and divergences of thymus- and peripherally derived regulatory T cells in cancer.Frontiers in immunology · 2013Article
- Anti-tumor effects of endogenous prostate cancer-specific CD8 T cells in a murine TCR transgenic model.The Prostate · 2012Article
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- Immunotherapy for prostate cancer: biology and therapeutic approaches.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2011Review
- Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression.Cancer cell · 2011Article
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Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
Tumors express a wide variety of both mutated and nonmutated Ags. Whether these tumor Ags are broadly recognized as self or foreign by the immune system is currently unclear. Using an autochthonous prostate cancer model in which hemagglutinin (HA) is specifically expressed in the tumor (ProHA x TRAMP mice), as well as an analogous model wherein HA is expressed in normal tissues as a model self-Ag (C3HA(high)), we examined the transcriptional profile of CD4 T cells undergoing Ag-specific division. Consistent with our previous data, transfer of Ag-specific CD4 T cells into C3HA(high) resulted in a functionally inactivated CD4 T cell profile. Conversely, adoptive transfer of an identical CD4 T cell population into ProHA x TRAMP mice resulted in the induction of a regulatory phenotype of the T cell (Treg) both at the transcriptional and functional level. Interestingly, this Treg skewing was a property of even early-stage tumors, suggesting Treg induction as an important tolerance mechanism during tumor development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.