ArticleEndocrinology2009
Influence of sex and corticotropin-releasing factor pathways as determinants in serotonin sensitivity.
Article in Endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies.Psychopharmacology · 2024Pooled it
- Review
- Withdrawal from chronic alcohol impairs the serotonin-mediated modulation of GABAergic transmission in the infralimbic cortex in male rats.Neurobiology of disease · 2024Article
- The role of brain serotonin signaling in excessive alcohol consumption and withdrawal: A call for more research in females.Neurobiology of stress · 2024Article
- Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice.Scientific reports · 2023Article
- In search of sex-related mediators of affective illness.Biology of sex differences · 2021Review
- CRF modulation of central monoaminergic function: Implications for sex differences in alcohol drinking and anxiety.Alcohol (Fayetteville, N.Y.) · 2018Review
- The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus.Nature neuroscience · 2018Article
- Sex differences in avoidance behavior after perceiving potential risk in mice.Behavioral and brain functions : BBF · 2017Article
- Overexpression of Forebrain CRH During Early Life Increases Trauma Susceptibility in Adulthood.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Efficacy of Tramadol as a Sole Analgesic for Postoperative Pain in Male and Female Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2015Article
- Prenatal stress-induced increases in placental inflammation and offspring hyperactivity are male-specific and ameliorated by maternal antiinflammatory treatment.Endocrinology · 2014Article
- Sex differences in corticotropin-releasing factor receptor-1 action within the dorsal raphe nucleus in stress responsivity.Biological psychiatry · 2014Article
- Dorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas.Biology of mood & anxiety disorders · 2014Article
- Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Sex differences in anxiety and emotional behavior.Pflugers Archiv : European journal of physiology · 2013Review
- Androgenic influence on serotonergic activation of the HPA stress axis.Endocrinology · 2011Article
- Evaluation of Pax6 mutant rat as a model for autism.PloS one · 2010Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
Stress sensitivity and sex are predictive factors in affective disorder susceptibility. Serotonin (5-HT) pathway recruitment by corticotropin-releasing factor (CRF) during stress is necessary in adaptive coping behaviors, but sex differences in such responses have not been investigated. Using selective 5-HT reuptake inhibitor (SSRI) administration to acutely elevate 5-HT in a genetic model of stress sensitivity, we examined behavioral and physiological responses in male and female stress-sensitive CRF receptor-2-deficient (R2KO) mice. Chronic SSRI treatment was used to confirm outcomes were specific to acute 5-HT elevation and not antidepressant efficacy. We hypothesized that R2KO mice would show a greater sensitivity to acute changes in 5-HT and that, because females typically are more stress sensitive, R2KO females would be the most responsive. Our results supported this hypothesis because females of both genotypes and R2KO males showed a greater sensitivity to an acute 10 mg/kg dose of citalopram in a tail suspension test, displaying decreased immobile time and increased latency to immobility. Furthermore, acute citalopram promoted significant anxiogenic-like effects that were specific to R2KO females in the elevated plus maze and light-dark box tests. Chronic citalopram did not produce these behavioral changes, supporting specificity to acute 5-HT modulation. Mechanistically, females had decreased hippocampal 5-HT transporter (SERT) levels, whereas R2KO mice showed reduced SERT in the prefrontal cortex, supporting a possible intersection of sex and genotype where R2KO females would have the lowest SERT to be blocked by the SSRI. This sensitivity to 5-HT-mediated anxiety in females may underlie a heightened vulnerability to stress-related affective disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.