ArticleVeterinary research
Myeloid differentiation factor 88 is required for resistance to Neospora caninum infection.
Article in Veterinary research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Mitochondrial damage and IL-1β production in monocytes caused byFrontiers in immunology · 2025Article
- Cytokine production by bovine adipose tissue stromal vascular fraction cells upon Neospora caninum stimulation.Scientific reports · 2024Article
- ThemSphere · 2023Article
- Article
- TNF-TNFR1 Signaling Enhances the Protection AgainstFrontiers in cellular and infection microbiology · 2021Article
- Congenital Transmission of Apicomplexan Parasites: A Review.Frontiers in microbiology · 2021Review
- ROS-mediated NLRP3 inflammasome activation participates in the response against Neospora caninum infection.Parasites & vectors · 2020Article
- Impact ofPathogens (Basel, Switzerland) · 2020Article
- Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected withPathogens (Basel, Switzerland) · 2020Article
- From Signaling Pathways to Distinct Immune Responses: Key Factors for Establishing or CombatingPathogens (Basel, Switzerland) · 2020Review
- Immediate Interferon Gamma Induction Determines Murine Host Compatibility Differences between Toxoplasma gondii and Neospora caninum.Infection and immunity · 2020Article
- Interplay Between Reactive Oxygen Species and the Inflammasome Are Crucial for Restriction ofFrontiers in cellular and infection microbiology · 2020Article
- Lytic cycle of Besnoitia besnoiti tachyzoites displays similar features in primary bovine endothelial cells and fibroblasts.Parasites & vectors · 2019Article
- Toll-Like Receptor 3-TRIF Pathway Activation byInfection and immunity · 2019Article
- Towards a preventive strategy for neosporosis: challenges and future perspectives for vaccine development against infection with Neospora caninum.The Journal of veterinary medical science · 2017Review
- Activation of ERK Signaling via TLR11 Induces IL-12p40 Production in Peritoneal Macrophages Challenged byFrontiers in microbiology · 2017Article
- Dectin-1 Compromises Innate Responses and Host Resistance againstFrontiers in immunology · 2017Article
- Nucleotide-binding oligomerization domain-containing protein 2 prompts potent inflammatory stimuli during Neospora caninum infection.Scientific reports · 2016Article
- Enrichment of IFN-γ producing cells in different murine adipose tissue depots upon infection with an apicomplexan parasite.Scientific reports · 2016Article
- Neospora caninum Activates p38 MAPK as an Evasion Mechanism against Innate Immunity.Frontiers in microbiology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neospora caninum is an intracellular parasite that causes major economic impact on cattle raising farms, and infects a wide range of warm-blooded hosts worldwide. Innate immune mechanisms that lead to protection against this parasite are still unknown. In order to investigate whether myeloid differentiation factor 88 (MyD88) is required for resistance against N. caninum, genetically deficient mice (MyD88(-/-)) and wild type littermates were infected with live tachyzoites and the resistance to infection was evaluated. We found that sub-lethal tachyzoite doses induced acute mortality of MyD88(-/-) mice, which succumbed to infection due to uncontrolled parasite replication. Higher parasitism in MyD88(-/-) mice was associated with the lack of IL-12 production by dendritic cells, delayed IFN-gamma responses by NKT, CD4(+) and CD8(+) T lymphocytes, and production of high levels of IL-10. MyD88(-/-) mice replenished with IL-12 and IFN-gamma abolished susceptibility as the animals survived throughout the experimental period. We conclude that protective IFN-gamma-mediated immunity to N. caninum is dependent on initial MyD88 signaling, in a mechanism triggered by production of IL-12 by dendritic cells. Further knowledge on Toll-like receptor recognition of N. caninum antigens is encouraged, since it could generate new prophylactic and therapeutic tools to control parasite burden.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.