ArticleNeuroscience and behavioral physiology2009
Electrophysiological studies of the effects of chronic administration of caffeine on the formation of a conditioned defensive reflex in the common snail.
Article in Neuroscience and behavioral physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Caffeine as a contaminant of periphyton: ecological changes and impacts on primary producers.Ecotoxicology (London, England) · 2021Article
- Black tea differs from green tea: it suppresses long-term memory formation inCommunicative & integrative biology · 2018Article
- The buzz on caffeine in invertebrates: effects on behavior and molecular mechanisms.Cellular and molecular life sciences : CMLS · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic administration of caffeine to common snails increased the rate of formation of a conditioned defensive reflex. When daily caffeine injections were given immediately after the training procedure, the conditioned defensive reflex was acquired more quickly than when caffeine injections were given before the training procedure started. Chronic caffeine administration to both trained and untrained snails led to depolarization changes in the membrane potential and reductions in the threshold potential of defensive behavior command neurons in common snails. Comparative studies showed that addition of caffeine to the solution bathing the mollusk nervous system resulted in decreases in the threshold potential of command neurons in both intact and trained snails; there was, however, no change in the membrane resting potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.