ArticleThe journal of physiological sciences : JPS2009
Involvement of aquaporin-5 in differentiation of human gastric cancer cells.
Article in The journal of physiological sciences : JPS, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 62 citations in OpenAlex.
- The role of Aquaporins in tumorigenesis: implications for therapeutic development.Cell communication and signaling : CCS · 2024Review
- Review
- Pathophysiological role of ion channels and transporters in HER2-positive breast cancer.Cancer gene therapy · 2022Review
- Deciphering the structure, function, expression and regulation of aquaporin-5 in cancer evolution.Oncology letters · 2021Review
- Expression and clinical significance of aquaporin-1, vascular endothelial growth factor and microvessel density in gastric cancer.Medicine · 2020Observational
- Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets.Pathology oncology research : POR · 2020Review
- Aquaporin 5 promotes tumor migration and angiogenesis in non-small cell lung cancer cell line H1299.Oncology letters · 2020Article
- Dynamics of Salivary Gland AQP5 under Normal and Pathologic Conditions.International journal of molecular sciences · 2020Review
- Aquaporin 5 promotes corneal wound healing.Experimental eye research · 2018Article
- Significance of aquaporins' expression in the prognosis of gastric cancer.Bioscience reports · 2018Article
- Effect of AQP-5 silencing by siRNA interference on chemosensitivity of breast cancer cells.OncoTargets and therapy · 2018Article
- Ion channels or aquaporins as novel molecular targets in gastric cancer.Molecular cancer · 2017Review
- Expression, Distribution and Role of Aquaporin Water Channels in Human and Animal Stomach and Intestines.International journal of molecular sciences · 2016Review
- Urine AQP5 is a potential novel biomarker of diabetic nephropathy.Journal of diabetes and its complications · 2016Article
- Aquaporin-5: from structure to function and dysfunction in cancer.Cellular and molecular life sciences : CMLS · 2016Review
- Aquaporins as diagnostic and therapeutic targets in cancer: how far we are?Journal of translational medicine · 2015Review
- Computing membrane-AQP5-phosphatidylserine binding affinities with hybrid steered molecular dynamics approach.Molecular membrane biology · 2015Article
- Cellular physiological approach for treatment of gastric cancer.World journal of gastroenterology · 2014Review
- AQP5 silencing suppresses p38 MAPK signaling and improves drug resistance in colon cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- The expression and role of Aquaporin 5 in esophageal squamous cell carcinoma.Journal of gastroenterology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Litttle is known about the function of aquaporin (AQP) water channels in human gastric cancer. In the upper or middle part of human stomach, we found that expression level of AQP5 protein in intestinal type of adenocarcinoma was significantly higher than that in accompanying normal mucosa. AQP5 was localized in the apical membrane of the cancer cells. On the other hand, both AQP3 and AQP4 were not up-regulated in the adenocarcinoma. To elucidate the role of AQP5 in cancer cells, AQP5 was exogenously expressed in a cell line of poorly differentiated human gastric adenocarcinoma (MKN45). The AQP5 expression significantly increased the proportion of differentiated cells with a spindle shape, the activity of alkaline phosphatase, a marker for the intestinal epithelial cell type of cancer cells, and the expression level of laminin, an epithelial cell marker. Treatment of the MKN45 cells stably expressing AQP5 with HgCl(2), an inhibitor of aquaporins, significantly decreased the proportion of differentiated cells and the activity of alkaline phosphatase. Our results suggest that up-regulation of AQP5 may be involved in differentiation of human gastric cancer cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.