ArticleInternational journal of hematology2009
Incidence of extramedullary disease in patients with acute promyelocytic leukemia: a single-institution experience.
Article in International journal of hematology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- Granulocytic sarcoma as an initial manifestation of acute promyelocytic leukemia: A case report with literature review.Medicine · 2025Review
- Different prognosis according to treatment in patients with acute promyelocytic leukemia: How the outcome changed over time.Annals of hematology · 2024Article
- Spinal myeloid sarcoma presenting as initial symptom in acute promyelocytic leukemia with a rare crypticFrontiers in oncology · 2024Article
- Case Report: Extramedullary Acute Promyelocytic Leukemia: An Unusual Case and Mini-Review of the Literature.Frontiers in oncology · 2022Article
- Myeloid sarcoma of the colon as initial presentation in acute promyelocytic leukemia: A case report and review of the literature.World journal of clinical cases · 2021Article
- Leukaemia cutis for clinicians, a literature review.Postepy dermatologii i alergologii · 2021Review
- Case Report: Very Late, Atypical Extra-Medullary Relapse in a Patient With Acute Promyelocytic Leukemia (APL) Rescued With a Transplant-Free Approach.Frontiers in oncology · 2021Article
- Diagnostic and Therapeutic Considerations for Extramedullary Leukemia.Current oncology reports · 2020Review
- Extramedullary disease in acute promyelocytic leukaemia: A rare presentation.SAGE open medical case reports · 2020Article
- Acute promyelocytic leukemia presenting as recurrent spinal myeloid sarcomas 3 years before developing leukemia: A case report with review of literature.Clinical case reports · 2019Article
- Central Nervous System Double Relapse of Acute Promyelocytic Leukemia and Acute Myelomonocytic Leukemia.Case reports in hematology · 2019Article
- A case of acute promyelocytic leukemia variant with derivative chromosome 3 der(3)t(3;8) associated with 8q partial gain.Molecular cytogenetics · 2019Article
- A Rare Case of Relapsed Pediatric Acute Promyelocytic Leukemia with Skin Involvement by Myeloid Sarcoma.The American journal of case reports · 2018Article
- Promyelocytic sarcoma of the right humerus: an unusual clinical presentation with unique diagnostic and treatment considerations.Clinical case reports · 2017Article
- Central nervous system involvement of acute promyelocytic leukemia, three case reports.Clinical case reports · 2017Article
- Current first- and second-line treatment options in acute promyelocytic leukemia.International journal of hematologic oncology · 2016Review
- Extramedullary Relapse of Acute Myeloid and Lymphoid Leukemia in Children: A Retrospective Analysis.Iranian journal of pediatrics · 2016Article
- [Clinical features and prognostic analysis of high-risk acute promyelocytic leukemia patients].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2016Article
- Myeloid sarcomas: a clinicopathologic study of 20 cases.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2015Article
- Acute appendicitis secondary to acute promyelocytic leukemia.The American journal of case reports · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Using current treatment regimens, over 90% of patients with acute promyelocytic leukemia will achieve complete remission (CR). However, approximately 30% of these patients will relapse, including a small proportion who will develop extramedullary disease (EMD). In this study, we investigated the incidence of EMD in 263 patients with APL who were treated at our institution from January 1990 to May 2008. With a median follow-up of 31 months (range 2 days-203 months), 8 (3%) patients developed EMD. The most commonly affected site was the central nervous system (n = 7). Before developing EMD, one patient had achieved CR with a chemotherapy-only regimen, six patients had achieved CR with all-trans-retinoic acid (ATRA)-based regimens, and one patient had achieved CR with an ATRA plus arsenic trioxide (ATO)-based regimen. The EMD conferred a poor prognosis; five patients died within 4 months of developing EMD. The molecular status did not predict EMD; four patients had a negative PCR for the PML-RARA transcripts prior to relapse with EMD. In conclusion, the incidence of EMD is low. We were unable to identify any specific factors that could predict the development of EMD.
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Registered trials
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