ArticleGenes & nutrition2009
Mammary gland zinc metabolism: regulation and dysregulation.
Article in Genes & nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- ZIP8 Regulates Inflammation and Macrophage Polarisation in Intervertebral Disc Degeneration via the Wnt/β-Catenin Pathway.Journal of cellular and molecular medicine · 2025Article
- Effects of Elevating Zinc Supplementation on the Health and Production Parameters of High-Producing Dairy Cows.Animals : an open access journal from MDPI · 2024Article
- NovelPediatric investigation · 2023Article
- A nutritional supplement containing zinc during preconception and pregnancy increases human milk zinc concentrations.Frontiers in nutrition · 2022Article
- Review
- Zinc Signaling in the Mammary Gland: For Better and for Worse.Biomedicines · 2021Review
- Synchrotron Radiation X-ray Fluorescence Elemental Mapping in Healthy versus Malignant Prostate Tissues Provides New Insights into the Glucose-Stimulated Zinc Trafficking in the Prostate As Discovered by MRI.Inorganic chemistry · 2019Article
- The Mediterranean Diet and Breast Cancer: A Personalised Approach.Healthcare (Basel, Switzerland) · 2019Review
- Molecular Mechanisms of Zinc as a Pro-Antioxidant Mediator: Clinical Therapeutic Implications.Antioxidants (Basel, Switzerland) · 2019Review
- Article
- Enhanced ZnR/GPR39 Activity in Breast Cancer, an Alternative Trigger of Signaling Leading to Cell Growth.Scientific reports · 2018Article
- Novel mutations in SLC30A2 involved in the pathogenesis of transient neonatal zinc deficiency.Pediatric research · 2016Article
- Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer.Molecular cancer · 2016Article
- Zn2+ efflux through lysosomal exocytosis prevents Zn2+-induced toxicity.Journal of cell science · 2014Article
- Article
- Imaging free zinc levels in vivo - what can be learned?Inorganica chimica acta · 2012Article
- Review
- A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity.PLoS genetics · 2012Article
- Zinc in specialized secretory tissues: roles in the pancreas, prostate, and mammary gland.Advances in nutrition (Bethesda, Md.) · 2011Review
- Loss of pluripotency in human embryonic stem cells directly correlates with an increase in nuclear zinc.PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Zinc (Zn) is required for numerous metabolic processes serving both a structural and catalytic role. The mammary gland has a unique Zn requirement resulting from the need to also transfer an extraordinary amount of Zn into milk (~0.5-1 mg Zn/day) during lactation. Impairments in this process can result in severe Zn deficiency in the nursing offspring which has adverse consequences with respect to growth and development. Moreover, dysregulated mammary gland Zn metabolism has recently been implicated in breast cancer transition, progression and metastasis, thus there is a critical need to understand the molecular mechanisms which underlie these observations. Tight regulation of Zn transporting mechanisms is critical to providing an extraordinary amount of Zn for secretion into milk as well as maintaining optimal cellular function. Expression of numerous Zn transporters has been detected in mammary gland or cultured breast cells; however, understanding the molecular mechanisms which regulate mammary Zn metabolism as well as the etiology and downstream consequences resulting from their dysregulation is largely not understood. In this review, we will summarize the current understanding of the regulation of mammary gland Zn metabolism and its regulation by reproductive hormones, with a discussion of the dysregulation of this process in breast cancer.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.