ReviewJournal of neural transmission (Vienna, Austria : 1996)2009
Anxiety in mice and men: a comparison.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- The role of the anterior cingulate cortex in anxiety control, from circuits to disorders.Frontiers in psychiatry · 2026Review
- Research progress on the neural circuits mechanisms of anxiety.Frontiers in neural circuits · 2025Review
- Genetics of behavioural evolution in giant mice from Gough Island.Proceedings. Biological sciences · 2023Article
- The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review.eNeuro · 2023Review
- Genomic analysis of firework fear and noise reactivity in standard poodles.Canine medicine and genetics · 2023Article
- The contribution of the flipped learning environment to value perception and controllability of classroom activities as antecedents of learners' anxiety: A control-value approach.Frontiers in psychology · 2022Review
- Associations between Depression, Anxiety, Fatigue, and Learning Motivating Factors in e-Learning-Based Computer Programming Education.International journal of environmental research and public health · 2021Article
- ADORA2A variation and adenosine ATranslational psychiatry · 2020Article
- Development and Psychometric Validation of the Lincoln Canine Anxiety Scale.Frontiers in veterinary science · 2020Article
- Early Recognition of Behaviour Problems in Shelter Dogs by Monitoring them in their Kennels after Admission to a Shelter.Animals : an open access journal from MDPI · 2019Article
- Effects of natural enrichment materials on stress, memory and exploratory behavior in mice.Lab animal · 2015Article
- Developmental rodent models of fear and anxiety: from neurobiology to pharmacology.British journal of pharmacology · 2014Review
- Prenatal bisphenol A exposure alters sex-specific estrogen receptor expression in the neonatal rat hypothalamus and amygdala.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal.The Journal of clinical investigation · 2012Article
- In search of optimal fear inducing stimuli: Differential behavioral responses to computer animated images in zebrafish.Behavioural brain research · 2012Article
- Article
- The autism diagnosis in translation: shared affect in children and mouse models of ASD.Autism research : official journal of the International Society for Autism Research · 2011Review
- The role of experimental models in developing new treatments for irritable bowel syndrome.Expert review of gastroenterology & hepatology · 2011Review
- Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice.Molecular brain · 2011Article
- Mapping functional brain activation using [14C]-iodoantipyrine in male serotonin transporter knockout mice.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anxiety is one of the most fundamental emotions required to survive or to cope with potential threatening stimuli. Under certain circumstances, it can change to excessive or maladaptive response and might manifest in anxious personality or even anxiety disorders. Genetic studies provide a number of promising candidate genes that, however, account for only a few percent of the phenotypic variance. Social and material environmental effects such as stressful life events, drugs or chemicals and particular behavioural influences such as parental care are suggested to interact with gene effects presumably involving epigenetic processes. Such interaction probably modifies an individual's predisposition, personality and susceptibility to develop normal or low anxiety or even maladaptive or excessive anxiety. Since human anxiety involves complex emotions as well as cognitions, unique experiences and an individual genetic make-up, studies trying to clarify the complex and functionally interwoven pathogenesis of anxious personality or anxiety disorders often adopt a reductionistic, simplifying approach. Therein, mice constitute an invaluable tool for modelling human anxiety in its various forms as they display remarkable similarities on anatomical, physiological, biochemical, molecular and behavioural levels. This review aims to fit observations and results obtained from men and mice on behavioural, genetic and environmental levels in response to different threatening stimuli elucidating different genetic and epigenetic effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.