ArticlePloS one2009
Manipulation of an innate escape response in Drosophila: photoexcitation of acj6 neurons induces the escape response.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 25 citations in OpenAlex.
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- Investigation of Seizure-Susceptibility in aGenetics · 2017Article
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- Optogenetic control of Drosophila using a red-shifted channelrhodopsin reveals experience-dependent influences on courtship.Nature methods · 2014Article
- mRNA localization in the Drosophila germline.RNA biology · 2014Review
- Optogenetic control of fly optomotor responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Optogenetic manipulation of neural circuits and behavior in Drosophila larvae.Nature protocols · 2012Article
- Analysis of functional neuronal connectivity in the Drosophila brain.Journal of neurophysiology · 2012Article
- Article
- Remote control of neuronal signaling.Pharmacological reviews · 2011Review
- Optogenetic investigation of neural circuits in vivo.Trends in molecular medicine · 2011Review
- The development and application of optogenetics.Annual review of neuroscience · 2011Review
- Comparative effects of heterologous TRPV1 and TRPM8 expression in rat hippocampal neurons.PloS one · 2009Article
- Studying Cerebellar Circuits by Remote Control of Selected Neuronal Types with GABA(A) Receptors.Frontiers in molecular neuroscience · 2009Article
- Ion channels to inactivate neurons in Drosophila.Frontiers in molecular neuroscience · 2009Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe genetic analysis of behavior in Drosophila melanogaster has linked genes controlling neuronal connectivity and physiology to specific neuronal circuits underlying a variety of innate behaviors. We investigated the circuitry underlying the adult startle response, using photoexcitation of neurons that produce the abnormal chemosensory jump 6 (acj6) transcription factor. This transcription factor has previously been shown to play a role in neuronal pathfinding and neurotransmitter modality, but the role of acj6 neurons in the adult startle response was largely unknown. PRINCIPAL
findingsWe show that the activity of these neurons is necessary for a wild-type startle response and that excitation is sufficient to generate a synthetic escape response. Further, we show that this synthetic response is still sensitive to the dose of acj6 suggesting that that acj6 mutation alters neuronal activity as well as connectivity and neurotransmitter production. RESULTS/SIGNIFICANCE: These results extend the understanding of the role of acj6 and of the adult startle response in general. They also demonstrate the usefulness of activity-dependent characterization of neuronal circuits underlying innate behaviors in Drosophila, and the utility of integrating genetic analysis into modern circuit analysis techniques.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.