ArticlePloS one2009
A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- MEOX2: a homeobox transcription factor with multifaceted biological functions and broad disease associations.Frontiers in cell and developmental biology · 2026Review
- Loss of fragile WWOX gene leads to senescence escape and genome instability.Cellular and molecular life sciences : CMLS · 2023Article
- Article
- Article
- FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16Aging cell · 2020Article
- Review
- HMGA Genes and Proteins in Development and Evolution.International journal of molecular sciences · 2020Review
- AProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Prognostic significance of MEOX2 in gliomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Article
- The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes.Oncogene · 2016Article
- The molecular balancing act of p16(INK4a) in cancer and aging.Molecular cancer research : MCR · 2014Review
- Overexpression of MEOX2 and TWIST1 is associated with H3K27me3 levels and determines lung cancer chemoresistance and prognosis.PloS one · 2014Article
- ETV1 positively regulates transcription of tumor suppressor ARF.Cancer biology & therapy · 2013Article
- Co-regulation of senescence-associated genes by oncogenic homeobox proteins and polycomb repressive complexes.Cell cycle (Georgetown, Tex.) · 2013Article
- Nanog reverses the effects of organismal aging on mesenchymal stem cell proliferation and myogenic differentiation potential.Stem cells (Dayton, Ohio) · 2012Article
- miRNAs involved in the generation, maintenance, and differentiation of pluripotent cells.Journal of molecular medicine (Berlin, Germany) · 2012Review
- Transcriptional regulation of cellular senescence.Oncogene · 2011Review
- Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.PloS one · 2011Article
- Characteristics of highly polymorphic segmental copy-number variations observed in Japanese by BAC-array-CGH.Journal of biomedicine & biotechnology · 2011Article
- Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221.Molecular and cellular biology · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CDKN2A locus encodes two important tumor suppressors, INK4a and ARF, which respond to oncogenic stresses by inducing cellular senescence. We conducted a genome-scale cDNA overexpression screen using a reporter containing INK4a regulatory sequences to identify novel transcriptional activators of this locus. This screen revealed 285 cDNAs that putatively regulate the transcriptional activation of INK4a. Of these, 56 are annotated as transcription factors, including two previously reported activators of the locus, ETS2 and JUNB. Fourteen genes were further validated for activity and specificity, including several homeodomain proteins. We found that the transcription of one of these, the homeodomain protein MEOX2 (GAX) is enhanced in primary cells during the induction of senescence, and forced expression of this protein results in the induction of premature senescence. We further demonstrate that MEOX2-induced senescence is dependent upon INK4a activity, and chromatin immunoprecipitation studies indicate that MEOX2 directly binds the INK4a promoter. These results support a role for this homeodomain protein as a direct regulator of INK4a transcription and senescence in human cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.