ArticlePloS one2009
PDK1 and HR46 gene homologs tie social behavior to ovary signals.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 62 citations in OpenAlex.
- Molecular signatures of alternative reproductive strategies in a facultatively social hover wasp.Molecular ecology · 2024Article
- Sterol and lipid metabolism in bees.Metabolomics : Official journal of the Metabolomic Society · 2023Review
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- Societies to genes: can we get there from here?Genetics · 2021Article
- Tachykinin signaling inhibits task-specific behavioral responsiveness in honeybee workers.eLife · 2021Article
- Core transcriptional signatures of phase change in the migratory locust.Protein & cell · 2019Article
- Differences in the morphology, physiology and gene expression of honey bee queens and workers rearedBiology open · 2018Article
- The dynamic association between ovariole loss and sterility in adult honeybee workers.Proceedings. Biological sciences · 2017Article
- Caste-biased gene expression in a facultatively eusocial bee suggests a role for genetic accommodation in the evolution of eusociality.Proceedings. Biological sciences · 2017Article
- Evolution of Social Insect Polyphenism Facilitated by the Sex Differentiation Cascade.PLoS genetics · 2016Article
- RNA-sequencing elucidates the regulation of behavioural transitions associated with the mating process in honey bee queens.BMC genomics · 2015Article
- Article
- Article
- Gene co-citation networks associated with worker sterility in honey bees.BMC systems biology · 2014Article
- Insulin-like peptides (AmILP1 and AmILP2) differentially affect female caste development in the honey bee (Apis mellifera L.).The Journal of experimental biology · 2013Article
- RNAi-mediated double gene knockdown and gustatory perception measurement in honey bees (Apis mellifera).Journal of visualized experiments : JoVE · 2013Article
- Article
- Complex pleiotropy characterizes the pollen hoarding syndrome in honey bees (Apis mellifera L.).Behavioral ecology and sociobiology · 2012Article
- Pleiotropy of segregating genetic variants that affect honey bee worker life expectancy.Experimental gerontology · 2012Article
- Gustatory perception and fat body energy metabolism are jointly affected by vitellogenin and juvenile hormone in honey bees.PLoS genetics · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The genetic basis of division of labor in social insects is a central question in evolutionary and behavioral biology. The honey bee is a model for studying evolutionary behavioral genetics because of its well characterized age-correlated division of labor. After an initial period of within-nest tasks, 2-3 week-old worker bees begin foraging outside the nest. Individuals often specialize by biasing their foraging efforts toward collecting pollen or nectar. Efforts to explain the origins of foraging specialization suggest that division of labor between nectar and pollen foraging specialists is influenced by genes with effects on reproductive physiology. Quantitative trait loci (QTL) mapping of foraging behavior also reveals candidate genes for reproductive traits. Here, we address the linkage of reproductive anatomy to behavior, using backcross QTL analysis, behavioral and anatomical phenotyping, candidate gene expression studies, and backcross confirmation of gene-to-anatomical trait associations. Our data show for the first time that the activity of two positional candidate genes for behavior, PDK1 and HR46, have direct genetic relationships to ovary size, a central reproductive trait that correlates with the nectar and pollen foraging bias of workers. These findings implicate two genes that were not known previously to influence complex social behavior. Also, they outline how selection may have acted on gene networks that affect reproductive resource allocation and behavior to facilitate the evolution of social foraging in honey bees.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.