ArticleGenes and immunity2009
Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population.
Article in Genes and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Variants in BANK1 are associated with lupus nephritis of European ancestry.Genes and immunity · 2021Pooled it
- Epistatic interaction between BANK1 and BLK in rheumatoid arthritis: results from a large trans-ethnic meta-analysis.PloS one · 2013Pooled it
- Genomic Landscape of Systemic Lupus Erythematosus and Lupus Nephritis Globally and the Gaps in Africa.International journal of molecular sciences · 2026Review
- Multi-omics investigation of prospective therapeutic targets for type 1 diabetes.Therapeutic advances in endocrinology and metabolism · 2025Article
- Review
- Clinical aspects and risk factors of lupus nephritis: a retrospective study of 156 adult patients.The Journal of international medical research · 2019Article
- BLK and BANK1 polymorphisms and interactions are associated in Mexican patients with systemic lupus erythematosus.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Article
- Exploring the etiopathogenesis of systemic lupus erythematosus: a genetic perspective.Immunogenetics · 2019Review
- Genome-wide association study of working memory brain activation.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- The BANK1 SLE-risk variants are associated with alterations in peripheral B cell signaling and development in humans.Clinical immunology (Orlando, Fla.) · 2016Article
- Genetics of Lupus Nephritis: Clinical Implications.Seminars in nephrology · 2015Review
- Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways.Journal of leukocyte biology · 2012Review
- Unraveling the genetic component of systemic sclerosis.Human genetics · 2012Review
- The dual effect of the lupus-associated polymorphism rs10516487 on BANK1 gene expression and protein localization.Genes and immunity · 2012Article
- Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK.Annals of the rheumatic diseases · 2012Article
- Effects of IRF5 lupus risk haplotype on pathways predicted to influence B cell functions.Journal of biomedicine & biotechnology · 2012Article
- The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis.Genes and immunity · 2010Article
- Genetic associations in type I interferon related pathways with autoimmunity.Arthritis research & therapy · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors at 13 institutions in 3 countries.
Funding
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease with highly variable clinical presentation. Patients suffer from immunological abnormalities that target T-cell, B-cell and accessory cell functions. B cells are hyperactive in SLE patients. An adapter protein expressed in B cells called BANK1 (B-cell scaffold protein with ankyrin repeats) was reported in a previous study to be associated with SLE in a European population. The objective of this study was to assess the BANK1 genotype-phenotype association in an independent replication sample. We genotyped 38 single nucleotide polymorphisms (SNPs) in BANK1 on 1892 European-derived SLE patients and 2652 European-derived controls. The strongest associations with SLE and BANK1 were at rs17266594 (corrected P-value=1.97 x 10(-5), odds ratio (OR)=1.22, 95% CI 1.12-1.34) and rs10516487 (corrected P-value=2.59 x 10(-5), OR=1.22, 95% CI 1.11-1.34). Our findings suggest that the association is explained by these two SNPs, confirming previous reports that these polymorphisms contribute to the risk of developing lupus. Analysis of patient subsets enriched for hematological, immunological and renal ACR criteria or the levels of autoantibodies, such as anti-RNP A and anti-SmRNP, uncovers additional BANK1 associations. Our results suggest that BANK1 polymorphisms alter immune system development and function to increase the risk for developing lupus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.