ReviewBehavioural pharmacology2009
Assessing the validity of current mouse genetic models of obsessive-compulsive disorder.
Review in Behavioural pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Neurobiology of Obsessive-Compulsive Disorder from Genes to Circuits: Insights from Animal Models.Neuroscience bulletin · 2024Review
- Chronic stress promotes basal ganglia disinhibition by increasing the excitatory drive of direct-pathway neurons.Neurobiology of stress · 2023Article
- EPD1504: a novel μ-opioid receptor partial agonist attenuates obsessive-compulsive disorder (OCD)-like behaviors.Frontiers in psychiatry · 2023Article
- Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice.Nature communications · 2022Article
- Bidirectional Behavioral Selection in Mice: A Novel Pre-clinical Approach to Examining Compulsivity.Frontiers in psychiatry · 2021Review
- Investigating the Role of Glutamate in Obsessive-Compulsive Disorder: Current Perspectives.Neuropsychiatric disease and treatment · 2020Review
- Obsessive-compulsive disorder: Insights from animal models.Neuroscience and biobehavioral reviews · 2017Review
- DISSECTING OCD CIRCUITS: FROM ANIMAL MODELS TO TARGETED TREATMENTS.Depression and anxiety · 2015Review
- Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Animal models of obsessive-compulsive disorder: utility and limitations.Neuropsychiatric disease and treatment · 2015Review
- From Thought to Action: How the Interplay Between Neuroscience and Phenomenology Changed Our Understanding of Obsessive-Compulsive Disorder.Frontiers in psychology · 2015Review
- Marble burying and nestlet shredding as tests of repetitive, compulsive-like behaviors in mice.Journal of visualized experiments : JoVE · 2013Article
- Dopaminergic control of cognitive flexibility in humans and animals.Frontiers in neuroscience · 2013Review
- Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders.Progress in neurobiology · 2012Review
- Essential role for orbitofrontal serotonin 1B receptors in obsessive-compulsive disorder-like behavior and serotonin reuptake inhibitor response in mice.Biological psychiatry · 2011Article
- Neurobiology of obsessive-compulsive disorder: insights into neural circuitry dysfunction through mouse genetics.Current opinion in neurobiology · 2011Review
- Predictive validity of a non-induced mouse model of compulsive-like behavior.Behavioural brain research · 2011Article
- Slitrks as emerging candidate genes involved in neuropsychiatric disorders.Trends in neurosciences · 2011Review
- Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice.Nature medicine · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Obsessive-compulsive disorder (OCD) is a disorder characterized by unwanted and intrusive thoughts, images, or impulses and/or repetitive behavior. OCD is a major cause of disability; however, the genetic factors and pathophysiological mechanisms underlying this complex, heterogeneous disorder remain largely unknown. During the past decade, a number of putative mouse genetic models of OCD have been developed for the purpose of studying the neural mechanisms underlying this disorder and developing novel treatments. This review presents and evaluates these experimental preparations to date. Models using knockout or transgenic approaches, as well as those examining variation in genetically diverse populations, are evaluated and discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.