ReviewThe Journal of clinical investigation2009
Bipolar disorder: from genes to behavior pathways.
Review in The Journal of clinical investigation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder.Molecular psychiatry · 2021Pooled it
- A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression.Archives of general psychiatry · 2010Trial
- Lithium-induced neuroprotection in bipolar disorder: Translational insights into cytoskeletal and proteomic mechanisms.IBRO neuroscience reports · 2025Review
- A Computational Ethology Approach for Characterizing Behavioral Dynamics in Bipolar Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Challenging the Safety Threshold: Neurotoxicity in Bipolar Disorder Treatment with Lithium at Therapeutic Serum Levels.Psychiatry and clinical psychopharmacology · 2025Article
- MAAT: a new nonparametric Bayesian framework for incorporating multiple functional annotations in transcriptome-wide association studies.Genome biology · 2025Article
- Study on association of serum uric acid levels with bipolar disorder: systematic review and meta-analysis in Chinese patients.Annals of general psychiatry · 2023Review
- Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes.Communications biology · 2022Article
- Lithium beyond psychiatric indications: the reincarnation of a new old drug.Neural regeneration research · 2021Review
- Call for Emergency Action to Limit Global Temperature Increases, Restore Biodiversity, and Protect Health.Alpha psychiatry · 2021Article
- Diacylglycerol kinase η colocalizes and interacts with apoptosis signal-regulating kinase 3 in response to osmotic shock.Biochemistry and biophysics reports · 2021Article
- SorCS2 is required for social memory and trafficking of the NMDA receptor.Molecular psychiatry · 2021Article
- Concepts of Neuroinflammation and Their Relationship With Impaired Mitochondrial Functions in Bipolar Disorder.Frontiers in behavioral neuroscience · 2021Review
- Abnormal Large-Scale Network Activation Present in Bipolar Mania and Bipolar Depression Under Resting State.Frontiers in psychiatry · 2021Article
- Microarray analysis of gene expression in the diacylglycerol kinase η knockout mouse brain.Biochemistry and biophysics reports · 2019Article
- Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook.Alcohol (Fayetteville, N.Y.) · 2019Review
- Latrophilins: A Neuro-Centric View of an Evolutionary Conserved Adhesion G Protein-Coupled Receptor Subfamily.Frontiers in neuroscience · 2019Article
- The impact of familial risk and early life adversity on emotion and reward processing networks in youth at-risk for bipolar disorder.PloS one · 2019Article
- Hypochondriac concerns and correlates of personality styles and affective states in bipolar I and II disorders.BMC psychiatry · 2018Article
- Antimanic Efficacy of a Novel Kv3 Potassium Channel Modulator.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Bipolar disorder (BPD) is a devastating illness that is characterized by recurrent episodes of mania and depression. In addition to these cyclic episodes, individuals with BPD exhibit changes in psychovegetative function, cognitive performance, and general health and well being. In this article we draw from neuroimaging findings in humans, postmortem data, and human genetic and pharmacological studies as well as data from animal models of behavior to discuss the neurobiology of BPD. We conclude with a synthesis of where the field stands and with suggestions and strategies for future areas of study to further increase our conceptual understanding of this complex illness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.