ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Splice-variant- and stage-specific RNA editing of the Drosophila GABA receptor modulates agonist potency.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
- Molecular Composition and Ligand Binding Characteristics of Native Ionotropic GABA Receptors in Rice Stem Borer,Insects · 2026Article
- A highly conserved A-to-I RNA editing event within the glutamate-gated chloride channel GluClα is necessary for olfactory-based behaviors inScience advances · 2024Article
- The molecular targets of ivermectin and lotilaner in the human louse Pediculus humanus humanus: New prospects for the treatment of pediculosis.PLoS pathogens · 2021Article
- The Fine Art of Writing a Message: RNA Metabolism in the Shaping and Remodeling of the Nervous System.Frontiers in molecular neuroscience · 2021Review
- Increased RNA editing in maternal immune activation model of neurodevelopmental disease.Nature communications · 2020Article
- Heterogeneous expression of GABA receptor-like subunits LCCH3 and GRD reveals functional diversity of GABA receptors in the honeybee Apis mellifera.British journal of pharmacology · 2020Article
- The cell line A-to-I RNA editing catalogue.Nucleic acids research · 2020Article
- In silico identification and assessment of insecticide target sites in the genome of the small hive beetle, Aethina tumida.BMC genomics · 2020Article
- RNA editing is abundant and correlates with task performance in a social bumblebee.Nature communications · 2019Article
- Illuminating spatial A-to-I RNA editing signatures within theProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cloning and Functional Characterisation of the Duplicated RDL Subunits from the Pea Aphid,International journal of molecular sciences · 2018Article
- How Complex Can Resistance to Dieldrin, the Insect γ-Aminobutyric Acid Receptor, Get?International journal of insect science · 2018Article
- Sequence variation between 462 human individuals fine-tunes functional sites of RNA processing.Scientific reports · 2016Article
- Large-scale detection and analysis of adenosine-to-inosine RNA editing during development in Plutella xylostella.Molecular genetics and genomics : MGG · 2015Article
- The emerging role of RNA editing in plasticity.The Journal of experimental biology · 2015Review
- Regulation of Ion Channel and Transporter Function Through RNA Editing.Current issues in molecular biology · 2015Review
- Temporal integration of cholinergic and GABAergic inputs in isolated insect mushroom body neurons exposes pairing-specific signal processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Molecular biology of insect sodium channels and pyrethroid resistance.Insect biochemistry and molecular biology · 2014Article
- The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster.Nucleic acids research · 2014Article
- Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The molecular diversity of many gene products functioning in the nervous system is enhanced by alternative splicing and adenosine-to-inosine editing of pre-mRNA. Using RDL, a Drosophila melanogaster GABA-gated ion channel, we examined the functional impact of RNA editing at several sites along with alternative splicing of more than one exon. We show that alternative splicing and RNA editing have a combined influence on the potency of the neurotransmitter GABA, and the editing isoforms detected in vivo span the entire functional range of potencies seen for all possible edit variants expressed in Xenopus laevis oocytes. The extent of RNA editing is developmentally regulated and can also be linked to the choice of alternative exons. These results provide insights into how the rich diversity of signaling necessary for complex brain function can be achieved by relatively few genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.