ArticleJournal of neurophysiology2009
Delay activity in rodent frontal cortex during a simple reaction time task.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed, 137 citations in OpenAlex.
- Cross-frequency coordination in a hippocampo-cortical circuit during probabilistic reversal learning.Communications biology · 2026Article
- Amphetamine increases timing variability by degrading prefrontal temporal encoding.Neuropharmacology · 2025Article
- An auditory cortical-striatal circuit supports sound-triggered timing to predict future events.PLoS biology · 2025Article
- The Role of Striatum in Controlling Waiting during Reactive and Self-Timed Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- Modeling saccade reaction time in marmosets: the contribution of earlier visual response and variable inhibition.Frontiers in systems neuroscience · 2024Article
- A Cortico-Striatal Circuit for Sound-Triggered Prediction of Reward Timing.bioRxiv : the preprint server for biology · 2023Article
- Impulse control disorder in Parkinson's disease is associated with abnormal frontal value signalling.Brain : a journal of neurology · 2023Article
- The PRO model accounts for the anterior cingulate cortex role in risky decision-making and monitoring.Cognitive, affective & behavioral neuroscience · 2022Article
- How do real animals account for the passage of time during associative learning?Behavioral neuroscience · 2022Article
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- Experience-related enhancements in striatal temporal encoding.The European journal of neuroscience · 2021Article
- Stay or go? Neuronal activity in medial frontal cortex during a voluntary tactile preference task in head-fixed mice.Cell calcium · 2021Article
- Medial prefrontal cortex and the temporal control of action.International review of neurobiology · 2021Review
- Visual Cues Predictive of Behaviorally Neutral Outcomes Evoke Persistent but Not Interval Timing Activity in V1, Whereas Aversive Conditioning Suppresses This Activity.Frontiers in systems neuroscience · 2021Article
- Serotonergic projections to the orbitofrontal and medial prefrontal cortices differentially modulate waiting for future rewards.Science advances · 2020Article
- Low-cost open hardware system for behavioural experiments simultaneously with electrophysiological recordings.HardwareX · 2020Article
- Temporal Deployment of Attention by Mental Training: an fMRI Study.Cognitive, affective & behavioral neuroscience · 2020Article
- Reward Timing and Its Expression by Inhibitory Interneurons in the Mouse Primary Visual Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To understand how different parts of the frontal cortex control the timing of action, we characterized the firing patterns of single neurons in two areas of rodent frontal cortex-dorsomedial prefrontal cortex (dmPFC) and motor cortex-during a simple reaction time task. Principal component analysis was used to identify major patterns of delay-related activity in frontal cortex: ramping activity and sustained delay activity. These patterns were similar in dmPFC and motor cortex and did not change as animals learned to respond at novel delays. Many neurons in both areas were modulated early in the delay period. Other neurons were modulated in a persistent manner over the duration of the delay period. Delay-related modulations started earlier in motor cortex than in dmPFC and terminated around different task events (at the time of release in dmPFC, just before release of the lever in motor cortex). A subpopulation of neurons was found in dmPFC, but not motor cortex, that fired in response to the trigger stimulus. These results suggest that populations of neurons in rodent frontal cortex are coordinated during delay periods to enable proactive inhibitory control of action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.