ArticleJournal of virology2009
Interleukin-12 (IL-12), but not IL-23, deficiency ameliorates viral encephalitis without affecting viral control.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 46 citations in OpenAlex.
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- Neurotropic EV71 causes encephalitis by engaging intracellular TLR9 to elicit neurotoxic IL12-p40-iNOS signaling.Cell death & disease · 2022Article
- Correlation between Cerebrospinal Fluid IL-12 Levels and Severity of Encephalopathy in Children.Journal of clinical medicine · 2021Article
- Th17 Cells in Viral Infections-Friend or Foe?Cells · 2021Review
- The Many Faces of JAKs and STATs Within the COVID-19 Storm.Frontiers in immunology · 2021Review
- Infection risk of dermatologic therapeutics during the COVID-19 pandemic: an evidence-based recalibration.International journal of dermatology · 2020Review
- Review
- T cell-selective deletion of Oct1 protects animals from autoimmune neuroinflammation while maintaining neurotropic pathogen response.Journal of neuroinflammation · 2019Article
- Distinct Gene Profiles of Bone Marrow-Derived Macrophages and Microglia During Neurotropic Coronavirus-Induced Demyelination.Frontiers in immunology · 2018Article
- The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance?Trends in immunology · 2017Review
- Activated GL7Brain, behavior, and immunity · 2017Article
- Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors.Neoplasia (New York, N.Y.) · 2016Article
- Self-reactive CD4(+) T cells activated during viral-induced demyelination do not prevent clinical recovery.Journal of neuroinflammation · 2015Article
- Article
- Distinct CD4 T-cell effects on primary versus recall CD8 T-cell responses during viral encephalomyelitis.Immunology · 2015Article
- IL-27 limits central nervous system viral clearance by promoting IL-10 and enhances demyelination.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis.Journal of neuroimmunology · 2014Article
- Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system.Virology · 2013Article
- MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis.ASN neuro · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The relative contributions of interleukin-12 (IL-12) and IL-23 to viral pathogenesis have not been extensively studied. IL-12p40 mRNA rapidly increases after neurotropic coronavirus infection. Infection of mice defective in both IL-12 and IL-23 (p40(-/-)), in IL-12 alone (p35(-/-)), and in IL-23 alone (p19(-/-)) revealed that the symptoms of coronavirus-induced encephalitis are regulated by IL-12. IL-17-producing cells never exceeded background levels, supporting a redundant role of IL-23 in pathogenesis. Viral control, tropism, and demyelination were all similar in p35(-/-), p19(-/-), and wild-type mice. Reduced morbidity in infected IL-12 deficient mice was also not associated with altered recruitment or composition of inflammatory cells. However, gamma interferon (IFN-gamma) levels and virus-specific IFN-gamma-secreting CD4 and CD8 T cells were all reduced in the central nervous systems (CNS) of infected p35(-/-) mice. Transcription of the proinflammatory cytokines IL-1beta and IL-6, but not tumor necrosis factor, were initially reduced in infected p35(-/-) mice but increased to wild-type levels during peak inflammation. Furthermore, although transforming growth factor beta mRNA was not affected, IL-10 was increased in the CNS in the absence of IL-12. These data suggest that IL-12 does not contribute to antiviral function within the CNS but enhances morbidity associated with viral encephalitis by increasing the ratio of IFN-gamma to protective IL-10.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.