ArticleThe Journal of infectious diseases2009
Identification of nevirapine-resistant HIV-1 in the latent reservoir after single-dose nevirapine to prevent mother-to-child transmission of HIV-1.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Slower clearance of nevirapine resistant virus in infants failing extended nevirapine prophylaxis for prevention of mother-to-child HIV transmission.AIDS research and human retroviruses · 2011Trial
- HIV DNA Sequencing to Detect Archived Antiretroviral Drug Resistance.Infectious diseases and therapy · 2022Review
- Protection of Newborn Macaques by Plant-Derived HIV Broadly Neutralizing Antibodies: a Model for Passive Immunotherapy during Breastfeeding.Journal of virology · 2021Article
- Human Immunodeficiency Virus Antiretroviral Resistance and Transmission in Mother-Infant Pairs Enrolled in a Large Perinatal Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Measuring turnover of SIV DNA in resting CD4+ T cells using pyrosequencing: implications for the timing of HIV eradication therapies.PloS one · 2014Article
- Impact of antiretroviral drugs in pregnant women and their children in Africa: HIV resistance and treatment outcomes.The Journal of infectious diseases · 2013Review
- Frequency and factors associated with adherence to and completion of combination antiretroviral therapy for prevention of mother to child transmission in western Kenya.Journal of the International AIDS Society · 2013Article
- Successful isolation of infectious and high titer human monocyte-derived HIV-1 from two subjects with discontinued therapy.PloS one · 2013Article
- An "escape clock" for estimating the turnover of SIV DNA in resting CD4⁺ T cells.PLoS pathogens · 2012Article
- Induction therapy with protease-inhibitors modifies the effect of nevirapine resistance on virologic response to nevirapine-based HAART in children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011Article
- Advances in prevention of mother-to-child HIV transmission: the international perspectives.Indian journal of pediatrics · 2011Review
- Emergence and persistence of minor drug-resistant HIV-1 variants in Ugandan women after nevirapine single-dose prophylaxis.PloS one · 2011Article
- Article
- Suboptimal nevirapine steady-state pharmacokinetics during intrapartum compared with postpartum in HIV-1-seropositive Ugandan women.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- Estimating frequencies of minority nevirapine-resistant strains in chronically HIV-1-infected individuals naive to nevirapine by using stochastic simulations and a mathematical model.Journal of virology · 2010Article
- Higher levels of Zidovudine resistant HIV in the colon compared to blood and other gastrointestinal compartments in HIV infection.Retrovirology · 2010Article
- Addition of 7 days of zidovudine plus lamivudine to peripartum single-dose nevirapine effectively reduces nevirapine resistance postpartum in HIV-infected mothers in Malawi.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- Nevirapine resistance by timing of HIV type 1 infection in infants treated with single-dose nevirapine.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2010Article
- Effects of highly active antiretroviral therapy duration and regimen on risk for mother-to-child transmission of HIV in Johannesburg, South Africa.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- Use of antiretrovirals during pregnancy and breastfeeding in low-income and middle-income countries.Current opinion in HIV and AIDS · 2010Review
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Authors and funding
18 authors at 8 institutions in 4 countries.
Funding
Abstract
backgroundIntrapartum single-dose nevirapine decreases mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) but promotes nevirapine resistance. Although resistant viruses fade to undetectable levels in plasma, they may persist as stably integrated proviruses within the latent reservoir in resting CD4(+) T cells, potentially complicating future treatment.
methodsBlood samples were collected from 60 women from South Africa and Uganda >6 months after they had received single-dose nevirapine. To selectively analyze the stable latent form of HIV-1, resting CD4(+) T cells were isolated and activated in the presence of reverse-transcriptase inhibitors and integrase inhibitors, which allows for the specific isolation of viruses produced by cells with stably integrated proviral DNA. These viruses were then analyzed for nevirapine resistance.
resultsAlthough only a small number of latently infected cells were present in each blood sample (mean, 162 cells), nevirapine resistance mutations (K103N and G190A) were detected in the latent reservoir of 4 (8%) of 50 evaluable women.
conclusionsA single dose of nevirapine can establish antiretroviral resistance within the latent reservoir. This results in a potentially lifelong risk of reemergence of nevirapine-resistant virus and highlights the need for strategies to prevent transmission that do not compromise successful future treatment.
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