ArticleNature genetics2009
Somatic and germline genetics at the JAK2 locus.
Article in Nature genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- The prognostic impact of germline 46/1 haplotype of Janus kinase 2 in cytogenetically normal acute myeloid leukemia.Haematologica · 2011Trial
- Trial
- Exploring hematological alterations and genetics linked to SNV rs10974944 in myeloproliferative neoplasms among Amazon patients.Scientific reports · 2024Article
- Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis.Nature genetics · 2023Article
- The Contribution ofInternational journal of molecular sciences · 2022Review
- Recent advances in hydrogels-based osteosarcoma therapy.Frontiers in bioengineering and biotechnology · 2022Review
- Germline Variants That Affect Tumor Progression.Trends in genetics : TIG · 2021Review
- Late-Onset Chorea inMovement disorders clinical practice · 2021Article
- The JAK2 GGCC (46/1) Haplotype in Myeloproliferative Neoplasms: Causal or Random?International journal of molecular sciences · 2018Review
- Future cancer research priorities in the USA: a Lancet Oncology Commission.The Lancet. Oncology · 2017Review
- Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer.Cancer discovery · 2017Article
- Common genetic variation in the germline influences where and how tumors develop.Molecular & cellular oncology · 2017Article
- Recent advances in understanding myelofibrosis and essential thrombocythemia.F1000Research · 2016Review
- JAK2 exon 14 skipping in patients with primary myelofibrosis: a minor splice variant modulated by the JAK2-V617F allele burden.PloS one · 2015Article
- Myelofibrosis 2012: it's complicated.Therapeutic advances in hematology · 2012Article
- Convergent mechanisms of somatic mutations in polycythemia vera.Discovery medicine · 2011Article
- Functional EGFR germline polymorphisms may confer risk for EGFR somatic mutations in non-small cell lung cancer, with a predominant effect on exon 19 microdeletions.Cancer research · 2011Article
- The Ph-positive and Ph-negative myeloproliferative neoplasms: some topical pre-clinical and clinical issues.Haematologica · 2011Review
- JAK2 46/1 haplotype analysis in myeloproliferative neoplasms and acute myeloid leukemia.Leukemia · 2010Article
- Chromosome 8q24-Associated Cancers and MYC.Genes & cancer · 2010Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Myeloproliferative neoplasms are hematological malignancies frequently associated with somatically acquired mutation of the JAK2 gene. A new study shows that these mutations are preferentially found within a particular inherited JAK2 haplotype, implying the existence of a strong, but uncharacterized, interaction between somatic and germline genetics at this locus.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.