Trial reportNeurocritical care2009
Induced normothermia attenuates intracranial hypertension and reduces fever burden after severe traumatic brain injury.
Trial report in Neurocritical care, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The Implementation of Targeted Temperature Management: An Evidence-Based Guideline from the Neurocritical Care Society.Neurocritical care · 2017Pooled it
- A Systematic Review of the Effects of Body Temperature on Outcome After Adult Traumatic Brain Injury.The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses · 2015Pooled it
- Pooled it
- Consensus summary statement of the International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care : a statement for healthcare professionals from the Neurocritical Care Society and the European Society of Intensive Care Medicine.Intensive care medicine · 2014Guideline
- Clinical review: Brain-body temperature differences in adults with severe traumatic brain injury.Critical care (London, England) · 2013Pooled it
- Hypothermia for Patients Requiring Evacuation of Subdural Hematoma: A Multicenter Randomized Clinical Trial.Neurocritical care · 2022Trial
- Esophageal Temperature Management in Patients Suffering from Traumatic Brain Injury.Therapeutic hypothermia and temperature management · 2019Trial
- Therapeutic Hypothermia for Neurological Injuries: Balancing Neuroprotection with Risks.Advances in experimental medicine and biology · 2026Review
- Optimizing Vital Signs in Patients With Traumatic Brain Injury: Reinforcement Learning Algorithm Development and Validation.Journal of medical Internet research · 2025Article
- A Modern Approach to the Treatment of Traumatic Brain Injury.Medicines (Basel, Switzerland) · 2024Review
- "THE MANTLE" bundle for minimizing cerebral hypoxia in severe traumatic brain injury.Critical care (London, England) · 2023Review
- "COAGULATION": a mnemonic device for treating coagulation disorders following traumatic brain injury-a narrative-based method in the intensive care unit.Frontiers in public health · 2023Article
- Effect of Fever on the Clinical Outcomes of Traumatic Brain Injury by Age.Medicina (Kaunas, Lithuania) · 2022Article
- Current and Potential Pharmacologic Therapies for Traumatic Brain Injury.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Management of Severe Traumatic Brain Injury in Pediatric Patients.Frontiers in toxicology · 2022Review
- Brain Temperature Influences Intracranial Pressure and Cerebral Perfusion Pressure After Traumatic Brain Injury: A CENTER-TBI Study.Neurocritical care · 2021Article
- The Association of Fever and Antipyretic Medication With Outcomes in Mechanically Ventilated Patients: A Cohort Study.Shock (Augusta, Ga.) · 2019Article
- Cooling via Trans-nasal High Flow Ambient Air: Does it Pass the Smell Test?Neurocritical care · 2019Article
- Retrospective Analysis of Esophageal Heat Transfer for Active Temperature Management in Post-cardiac Arrest, Refractory Fever, and Burn Patients.Military medicine · 2018Article
- Targeted temperature management in the ICU: guidelines from a French expert panel.Annals of intensive care · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
introductionHyperthermia following a severe traumatic brain injury (TBI) is common, potentiates secondary injury, and worsens neurological outcome. Conventional fever treatment is often ineffective. An induced normothermia protocol, utilizing intravascular cooling, was used to assess the impact on fever incidence and intracranial pressure (ICP) in patients with severe TBI.
methodsA comparative cohort study of 21 adult patients with severe TBI (GCS <or= 8) treated with induced normothermia [36-36.5 degrees C rectal probe setting; intravascular cooling catheter (CoolLine, Alsius Corporation, Irvine, CA)] were matched by age, gender, and severity of injury to 21 historical control severe TBI patients treated with conventional fever control methods. ICP was measured via an external ventricular catheter and time duration for ICP > 25 mmHg was calculated for the initial 72-h monitoring period. Non-parametric rank tests were performed.
resultsMean (+/-SD) or median [range] demographics did not differ between groups [total N = 42 (6 female, 36 male, age 36.4 +/- 14.8 years and initial GCS 7 [3-8], median and range]. Fever burden in the first 3 days (time >38 degrees C) in the induced normothermia versus control group was significantly less at 1.6% versus 10.6%, respectively (P = 0.03). Mean ICP for patients with induced normothermia versus control was 12.74 +/- 4.0 and 16.37 +/- 6.9 mmHg, respectively. Furthermore, percentage of time with ICP > 25 mmHg was significantly less in the induced normothermia group (P = 0.03).
conclusionInduced normothermia (fever prophylaxis via intravascular cooling catheter) is effective in reducing fever burden and may offer a means to attenuate secondary injury, as evidenced by a reduction in the intracranial hypertension burden.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.