SynthesisHuman genetics2009
ATG16L1 T300A polymorphism and Crohn's disease susceptibility: evidence from 13,022 cases and 17,532 controls.
Synthesis in Human genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Population stratified differences between ATG16L1 rs2241880 polymorphism with Crohn's disease risk: a systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- Differentially Expressed miRNAs in Ulcerative Colitis and Crohn's Disease.Frontiers in immunology · 2022Pooled it
- Complement factor H Y402H gene polymorphism and coronary heart disease susceptibility: a meta-analysis.Molecular biology reports · 2011Pooled it
- T300A polymorphism of ATG16L1 and susceptibility to inflammatory bowel diseases: a meta-analysis.World journal of gastroenterology · 2010Pooled it
- Unraveling the Pathogenetic Potential and Immune Crosstalk of Yersinia spp. in Inflammatory Bowel Disease.Journal of immunology research · 2026Review
- Association between ATG16L1 rs2241880(T300A) and rs4663421 and ANCA‑associated vasculitis in the Guangxi population of China: Propensity score matching analysis.Biomedical reports · 2025Article
- A loss-of-function polymorphism inOncoimmunology · 2022Article
- Autophagy ATG16L1 rs2241880 impacts the colorectal cancer risk: A case-control study.Journal of clinical laboratory analysis · 2022Article
- Thiopurines correct the effects of autophagy impairment on intestinal healing - a potential role for ARHGAP18/RhoA.Disease models & mechanisms · 2021Article
- Association between variants of the autophagy related gene ATG16L1 in inflammatory bowel diseases and clinical statues.Gastroenterology and hepatology from bed to bench · 2019Article
- Article
- Microbial Disruption of Autophagy Alters Expression of the RISC Component AGO2, a Critical Regulator of the miRNA Silencing Pathway.Inflammatory bowel diseases · 2015Article
- MicroRNA signatures differentiate Crohn's disease from ulcerative colitis.BMC immunology · 2015Article
- Inflammatory bowel disease in pediatric and adolescent patients: a biomolecular and histopathological review.World journal of gastroenterology · 2014Article
- Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1β (IL-1β).The Journal of biological chemistry · 2013Article
- Autophagy in immunity: implications in etiology of autoimmune/autoinflammatory diseases.Autophagy · 2012Review
- The role of autophagy in Crohn's disease.Cells · 2012Article
- Evaluation of 22 genetic variants with Crohn's disease risk in the Ashkenazi Jewish population: a case-control study.BMC medical genetics · 2011Article
- Inflammasome-independent modulation of cytokine response by autophagy in human cells.PloS one · 2011Article
- Race and inflammatory bowel disease in an urban healthcare system.Digestive diseases and sciences · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many studies have reported the association between the autophagy-related 16-like 1 gene (ATG16L1) T300A polymorphism (rs2241880) and Crohn's disease (CD) susceptibility, but the results were inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 24 studies including 13,022 cases and 17,532 controls were included in this meta-analysis. Logistic regression analysis indicated that the ATG16L1 T300A polymorphism was associated with CD risk in Caucasians (P < 0.01). The pooled estimations of OR(1) (GG vs. AA) and OR(2) (GA vs. AA) in Caucasian studies by Bayesian meta-analysis method was [1.87, 95% confidence interval (CI) 1.69-2.05] and (1.39, 95% CI 1.27-1.51), respectively. The mode of heritance of the G allele was most likely to be co-dominant in Caucasians. However, no significant association was found in Asians. This meta-analysis suggests that the G allele of ATG16L1 T300A is a low-penetrant gene for developing CD in Caucasians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.